SLC25A42 - solute carrier family 25 member 42 Gene

Also Known as MECREN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 284439

About SLC25A42

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,063,994-19,113,030 (from NCBI)

This gene has 6 transcripts (splice variants), 249 orthologues, 49 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 18.3), liver (RPKM 12.3) and 24 other tissues.

Summary

This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]

SLC25A42 Products (2)

mRNA	Protein	Name
NM_001321544.2	NP_001308473.1	mitochondrial coenzyme A transporter SLC25A42
NM_178526.5	NP_848621.2	mitochondrial coenzyme A transporter SLC25A42

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP phosphatase activity	IDA IDA: Inferred from direct assay	19429682	GOA
enables ADP transmembrane transporter activity	IDA IDA: Inferred from direct assay	19429682	GOA
enables AMP transmembrane transporter activity	IDA IDA: Inferred from direct assay	19429682	GOA
enables ATP transmembrane transporter activity	IDA IDA: Inferred from direct assay	19429682	GOA
enables coenzyme A transmembrane transporter activity	EXP EXP: Inferred from Experiment	19429682	GOA
enables coenzyme A transmembrane transporter activity	IDA IDA: Inferred from direct assay	19429682	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ADP transport	IDA IDA: Inferred from direct assay	19429682	GOA
involved in AMP transport	IDA IDA: Inferred from direct assay	19429682	GOA
involved in ATP transport	IDA IDA: Inferred from direct assay	19429682	GOA
involved in coenzyme A transmembrane transport	IDA IDA: Inferred from direct assay	19429682	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	19429682	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A42 Protein Structure

Mito_carr

0
100
200
300
318 a.a.

Protein Preferred Names	Protein Names
mitochondrial coenzyme A transporter SLC25A42

SLC25A42 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC25A42	Q86VD7	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	SLC25A42	Q86VD7	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	SLC25A42	Q86VD7	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	SLC25A42	Q86VD7	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	SLC25A42	Q86VD7	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	SLC25A42	Q86VD7	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	SLC25A42	Q86VD7	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	SLC25A42	Q86VD7	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Metabolic Crises, Recurrent, With Variable Encephalomyopathic Features And Neurologic Regression	MECREN
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 2	PEOA2 Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 2 Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2 Chronic Progressive External Ophthalmoplegia Progressive External Ophthalmoplegia, Autosomal Dominant 2 Autosomal Dominant Progressive External Ophthalmoplegia 2 Cpeo Graefe Disease Mitochondrial Ocular Myopathy Ocular Myopathy Of Von Graefe-Fuchs Progressive External Ophthalmoplegia Autosomal Dominant 2 Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 2 Kearns-Sayre Syndrome
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic
Combined D-2- And L-2-Hydroxyglutaric Aciduria	D,L-2-Hydroxyglutaric Aciduria D2L2AD Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria D,L-2-Hga D,L-2-Hydroxyglutaric Acidemia Combined D,L-2-Hydroxyglutaric Aciduria
Developmental And Epileptic Encephalopathy 39	Hypomyelination, Global Cerebral Agc1 Deficiency Epileptic Encephalopathy, Early Infantile, 39 DEE39 Eiee39 Aspartate-Glutamate Carrier 1 Deficiency Epileptic Encephalopathy With Global Cerebral Demyelination Developmental And Epileptic Encephalopathy, 39 Early Infantile Epileptic Encephalopathy 39 Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency Global Cerebral Hypomyelination Hereditary Central Nervous System Demyelinating Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13124	SLC25A42 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC25A42	VGNC	VGNC:46313
Felis catus	SLC25A42	VGNC	VGNC:65276
Bos taurus	SLC25A42	VGNC	VGNC:34767
Macaca mulatta	SLC25A42	VGNC	VGNC:77579
Mus musculus	SLC25A42	MGD	MGI:1920345
Rattus norvegicus	SLC25A42	RGD	RGD:1592346