SLC25A42 - solute carrier family 25 member 42 Gene

Homo sapiens

Also known as MECREN

Gene ID: 284439 | Gene type: protein coding

About SLC25A42

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,063,994-19,113,030 (from NCBI)

This gene has 6 transcripts (splice variants), 249 orthologues, 49 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 18.3), liver (RPKM 12.3) and 24 other tissues.

Summary

This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]

SLC25A42 Products(2)

mRNA	Protein	Name
NM_001321544.2	NP_001308473.1	mitochondrial coenzyme A transporter SLC25A42
NM_178526.5	NP_848621.2	mitochondrial coenzyme A transporter SLC25A42

SLC25A42 Protein Structure

Mito_carr

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

mitochondrial coenzyme A transporter SLC25A42

Related Diseases

Diseases

Alias

Metabolic Crises, Recurrent, With Variable Encephalomyopathic Features And Neurologic Regression

MECREN

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 2

PEOA2	Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 2
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2	Chronic Progressive External Ophthalmoplegia
Progressive External Ophthalmoplegia, Autosomal Dominant 2	Autosomal Dominant Progressive External Ophthalmoplegia 2
Cpeo	Graefe Disease
Mitochondrial Ocular Myopathy	Ocular Myopathy Of Von Graefe-Fuchs
Progressive External Ophthalmoplegia Autosomal Dominant 2	Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 2
Kearns-Sayre Syndrome

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Combined D-2- And L-2-Hydroxyglutaric Aciduria

D,L-2-Hydroxyglutaric Aciduria	D2L2AD
Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia	Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria
D,L-2-Hga	D,L-2-Hydroxyglutaric Acidemia
Combined D,L-2-Hydroxyglutaric Aciduria

Developmental And Epileptic Encephalopathy 39

Hypomyelination, Global Cerebral	Agc1 Deficiency
Epileptic Encephalopathy, Early Infantile, 39	DEE39
Eiee39	Aspartate-Glutamate Carrier 1 Deficiency
Epileptic Encephalopathy With Global Cerebral Demyelination	Developmental And Epileptic Encephalopathy, 39
Early Infantile Epileptic Encephalopathy 39	Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency
Global Cerebral Hypomyelination	Hereditary Central Nervous System Demyelinating Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13124	SLC25A42 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC25A42	VGNC	VGNC:46313
Felis catus	SLC25A42	VGNC	VGNC:65276
Bos taurus	SLC25A42	VGNC	VGNC:34767
Macaca mulatta	SLC25A42	VGNC	VGNC:77579
Mus musculus	SLC25A42	MGD	MGI:1920345
Rattus norvegicus	SLC25A42	RGD	RGD:1592346

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