Shmt1 - serine hydroxymethyltransferase 1 Gene

Also Known as Shmt; mShmt; LRRGT00032

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287379

Summary

Enables several functions, including L-allo-threonine aldolase activity; glycine hydroxymethyltransferase activity; and pyridoxal phosphate binding activity. Involved in glycine biosynthetic process from serine. Located in cytosol. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Shmt1 Products (1)

mRNA Protein Name
NM_001413151.1 NP_001400080.1 serine hydroxymethyltransferase, cytosolic

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-allo-threonine aldolase activity IDA
IDA: Inferred from direct assay
3110140 RGD
enables amino acid binding IPI
IPI: Inferred from physical interaction
3110140 RGD
enables glycine hydroxymethyltransferase activity IDA
IDA: Inferred from direct assay
3110140 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
3110140 RGD
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
3110140 RGD
Biological Process GO Annotation Evidence References Source
involved in glycine biosynthetic process IDA
IDA: Inferred from direct assay
3110140 RGD
involved in glycine biosynthetic process from serine IDA
IDA: Inferred from direct assay
3110140 RGD
involved in glycine metabolic process IDA
IDA: Inferred from direct assay
15671219 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine hydroxymethyltransferase, cytosolic

  • serine hydroxymethyltransferase 1 (soluble)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178432 SHMT2-IN-1 Inhibitor / Unkown
HY-148545 SHMT-IN-3 Inhibitor ≥98.0% Unkown
HY-177092 AGF347 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shmt1 NCBI NCBI:6470