GPX7 - glutathione peroxidase 7 Gene

Also Known as GPX6; CL683; GPx-7; NPGPx; GSHPx-7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2882

About GPX7

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,602,371-52,609,051 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 7 paralogues. Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 9.2) and 24 other tissues.

Summary

Enables catalase activity. Predicted to be involved in cellular response to oxidative stress. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

GPX7 Products (1)

mRNA	Protein	Name
NM_015696.5	NP_056511.2	glutathione peroxidase 7 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables catalase activity	IDA IDA: Inferred from direct assay	22157330	GOA
enables peroxidase activity	EXP EXP: Inferred from Experiment	21215271	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21215271	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPX7 Protein Structure

GSHPx

0
100
187 a.a.

Protein Preferred Names	Protein Names
glutathione peroxidase 7	glutathione peroxidase 6

GPX7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GPX7	Q96SL4	CPNE7	Homo sapiens	Q9UBL6-2	Validated Y2H	32296183
Intra	GPX7	Q96SL4	GET3	Homo sapiens	O43681	Y2H Prey Pooling	25416956
Intra	GPX7	Q96SL4	GET3	Homo sapiens	O43681	Validated Y2H	25416956
Intra	GPX7	Q96SL4	SGTA	Homo sapiens	O43765	Y2H Pooling	16189514
Intra	GPX7	Q96SL4	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	GPX7	Q96SL4	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	GPX7	Q96SL4	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	GPX7	Q96SL4	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	GPX7	Q96SL4	TCF25	Homo sapiens	Q9BQ70	Validated Y2H	32296183
Intra	GPX7	Q96SL4	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GPX7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75798	GPX7 Protein, Human (HEK293, Fc)	Q96SL4/NP_056511.2 (Q20-L187)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Barrett'S Adenocarcinoma	Barrett Adenocarcinoma Adenocarcinoma Arising In Barrett'S Mucosa
Esophagus Adenocarcinoma	Esophageal Adenocarcinoma Oesophageal Adenocarcinoma Adenocarcinoma Of Esophagus Adenocarcinoma Of The Esophagus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05770	GPX7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19337	Gpx7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25828	Gpx7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPX7	RGD	RGD:1306999
Macaca mulatta	GPX7	VGNC	VGNC:73155
Felis catus	GPX7	VGNC	VGNC:67454
Bos taurus	GPX7	VGNC	VGNC:29621
Mus musculus	GPX7	MGD	MGI:1914555
Others	GPX7	NCBI