Fis1 - fission, mitochondrial 1 Gene

Also Known as Ttc11

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 288584

Summary

Enables identical protein binding activity. Involved in several processes, including cellular response to thapsigargin; mitochondrial fragmentation involved in apoptotic process; and positive regulation of mitochondrial fission. Located in mitochondrion and peroxisomal membrane. Is integral component of mitochondrial outer membrane. Biomarker of dental fluorosis; fatty liver disease; kidney failure (multiple); myocardial infarction; and rhinitis. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Apr 2022]

Fis1 Products (2)

mRNA Protein Name
NM_001105919.2 NP_001099389.1 mitochondrial fission 1 protein isoform 1
NM_001401051.1 NP_001387980.1 mitochondrial fission 1 protein isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
27684054 RGD
involved in cellular response to lipid IEP
IEP: Inferred from expression pattern
18006463 RGD
involved in cellular response to peptide IDA
IDA: Inferred from direct assay
24103571 RGD
involved in cellular response to toxic substance IEP
IEP: Inferred from expression pattern
26732598 RGD
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
18940801 RGD
involved in positive regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
15979461 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18940801 RGD
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
17443673 RGD
involved in response to flavonoid IEP
IEP: Inferred from expression pattern
24637344 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
23007560 RGD
involved in response to hypobaric hypoxia IEP
IEP: Inferred from expression pattern
24361501 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
24943897 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25336449 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
15979461 RGD
located in peroxisomal membrane IDA
IDA: Inferred from direct assay
16107562 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
14561759 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial fission 1 protein

  • TPR repeat protein 11

  • fis1 homolog

  • fission 1 (mitochondrial outer membrane) homolog

  • rFis1

  • tetratricopeptide repeat domain 11

  • tetratricopeptide repeat protein 11

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10368 P110 heptapeptide Inhibitor 99.98% Unkown
HY-P2280 TAT-P110 Inhibitor 99.95% Unkown
HY-139109 IR-783 99.46% Unkown
HY-172942 SP11 Inhibitor 98.91% Unkown
HY-155656 Anti-inflammatory agent 49 Inhibitor 99.44% Unkown
HY-RS04951 FIS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19331 Fis1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25822 Fis1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fis1 NCBI NCBI:51024