FIS1 - fission, mitochondrial 1 Gene

Also Known as TTC11; CGI-135

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51024

About FIS1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,239,472-101,245,081 (from NCBI)

This gene has 9 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in heart (RPKM 77.0), thyroid (RPKM 71.6) and 25 other tissues.

Summary

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

FIS1 Products (1)

mRNA	Protein	Name
NM_016068.3	NP_057152.2	mitochondrial fission 1 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18353969	GOA
enables lipid binding	EXP EXP: Inferred from Experiment	14623186	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	14623186	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12861026	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial fission	IDA IDA: Inferred from direct assay	16118244	GOA
involved in mitochondrial fission	IMP IMP: Inferred from mutant phenotype	18353969	GOA
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	21149567	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	18845145	GOA
involved in negative regulation of ATP metabolic process	IMP IMP: Inferred from mutant phenotype	32521232	GOA
involved in negative regulation of fatty acid transport	IMP IMP: Inferred from mutant phenotype	32521232	GOA
involved in peroxisome fission	IDA IDA: Inferred from direct assay	16107562	GOA
involved in peroxisome fission	IMP IMP: Inferred from mutant phenotype	20826455	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21183955	GOA
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	18845145	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	14996942	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	17408615	GOA
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	16107562	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	18782765	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17408615	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FIS1 Protein Structure

Fis1_TPR_N

Fis1_TPR_C

0
100
152 a.a.

Protein Preferred Names	Protein Names
mitochondrial fission 1 protein	FIS1 homolog

FIS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FIS1	Q9Y3D6	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	TMPPE	Homo sapiens	Q6ZT21	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	TMPPE	Homo sapiens	Q6ZT21	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	PIGP	Homo sapiens	P57054	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	PIGP	Homo sapiens	P57054	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	SLC14A1	Homo sapiens	Q13336-2	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	SLC14A1	Homo sapiens	Q13336-2	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	APH1A	Homo sapiens	Q96BI3	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	APH1A	Homo sapiens	Q96BI3	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	ABHD6	Homo sapiens	Q9BV23	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	ABHD6	Homo sapiens	Q9BV23	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	MIEF1	Homo sapiens	Q9NQG6	Anti Tag CoIP	21701560
Intra	FIS1	Q9Y3D6	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	FIS1	Q9Y3D6	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	FIS1	Q9Y3D6	BCAP31	Homo sapiens	P51572	Anti Tag CoIP	21183955
Intra	FIS1	Q9Y3D6	BCAP31	Homo sapiens	P51572	Anti Bait CoIP	21183955
Intra	FIS1	Q9Y3D6	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	FIS1	Q9Y3D6	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	FIS1	Q9Y3D6	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FIS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70941	FIS1 Protein, Human (His)	Q9Y3D6 (M1-G122)	≥ 95%, as determined by reducing SDS-PAGE.

FIS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82353	Mitochondrial Fission 1 Protein Antibody (YA2098)	WB, IHC-P, ICC/IF	Human, Cow

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 12	Spinocerebellar Ataxia Type 12 SCA12 Ataxia, Spinocerebellar, Type 12
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Charcot-Marie-Tooth Disease, Axonal, Type 2k	Charcot-Marie-Tooth Disease Axonal Type 2k CMT2K Autosomal Recessive Charcot-Marie-Tooth Disease With Hoarseness Arcmt2k Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2k Autosomal Recessive Axonal Cmt4c4 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2k Charcot-Marie-Tooth Neuropathy, Axonal, Type 2k Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2k Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Disease Type 2k Charcot-Marie-Tooth Neuropathy Axonal Type 2k Autosomal Dominant Charcot-Marie-Tooth Disease Type 2k Charcot-Marie-Tooth Disease 2k Charcot-Marie-Tooth Disease Neuronal Type 2k Charcot-Marie-Tooth Neuropathy Type 2k Charcot-Marie-Tooth Disease, Type 2k
Cranial Nerve Disease	Cranial Nerve Disorder Disorder Of Cranial Nerve Cranial Nerve Diseases
Optic Atrophy 11	OPA11 Atrophy, Optic, Type 11
Myopathy, Centronuclear, 1	Autosomal Dominant Centronuclear Myopathy CNM1 Centronuclear Myopathy 1 Ad-Cnm Myopathy, Centronuclear, Autosomal Dominant Myotubular Myopathy, Autosomal Dominant Centronuclear Myopathy, Autosomal, Modifier Of Autosomal Dominant Myotubular Myopathy Dnm2-Related Centronuclear Myopathy Centronuclear Myopathy Autosomal Dominant Myopathies, Structural, Congenital Myopathy, Centronuclear, Type 1
Charcot-Marie-Tooth Disease, Type 4a	Charcot-Marie-Tooth Disease Type 4a CMT4A Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4a Charcot-Marie-Tooth Neuropathy, Type 4a Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4a Charcot-Marie-Tooth Neuropathy Type 4a Charcot-Marie-Tooth Disease 4a Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive, Type 4a Charcot-Marie-Tooth Disease Neuropathy Type 4a
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Optic Atrophy 3, Autosomal Dominant	Optic Atrophy 3 OPA3 Autosomal Dominant Optic Atrophy And Cataract Optic Atrophy And Cataract, Autosomal Dominant Autosomal Dominant Optic Atrophy Type 3 Optic Atrophy 3 With Cataract Opa3, Autosomal Dominant Adoac Optic Atrophy, Cataract, And Neurologic Disorder Autosomal Dominant Optic Atrophy 3 Optic Atrophy Type 3 Optic Atrophy 3 Autosomal Dominant Atrophy, Optic, Type 3, Autosomal Dominant 3-Methylglutaconic Aciduria Type 3
Loeys-Dietz Syndrome 4	LDS4 Aneurysm, Aortic And Cerebral, With Arterial Tortuosity And Skeletal Manifestations Loeys-Dietz Syndrome Type 4 Aortic And Cerebral Aneurysm With Arterial Tortuosity And Skeletal Manifestations Loeys-Dietz Syndrome, Type 4
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Leber Hereditary Optic Neuropathy, Modifier Of	Leber Optic Atrophy Leber Hereditary Optic Neuropathy LHON Leber'S Hereditary Optic Neuropathy Leber Optic Atrophy, Susceptibility To Leber'S Optic Atrophy LOAM Loas Leber'S Disease Leber'S Optic Neuropathy Optic Atrophy, Hereditary, Leber Lhon, Modifier Of Optic Atrophy, Leber Type Hereditary Optic Neuroretinopathy Leber Hereditary Optic Atrophy Loa Optic Atrophy Leber Type Leber Hereditary Optic Neuropathy, Modifier Leber Hereditary Optic Neuropathy Susceptibility Modifier Of Leber Hereditary Optic Neuropathy Lebers Hereditary Optic Neuropathy Leber Congenital Amaurosis
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10368	P110 heptapeptide	Inhibitor	99.98%	Unkown
HY-P2280	TAT-P110	Inhibitor	99.95%	Unkown
HY-139109	IR-783		99.46%	Unkown
HY-172942	SP11	Inhibitor	98.91%	Unkown
HY-155656	Anti-inflammatory agent 49	Inhibitor	99.44%	Unkown
HY-RS04951	FIS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19331	Fis1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25822	Fis1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FIS1	RGD	RGD:1306668
Felis catus	FIS1	VGNC	VGNC:62275
Bos taurus	FIS1	VGNC	VGNC:29014
Canis familiaris	FIS1	VGNC	VGNC:40884
Macaca mulatta	FIS1	VGNC	VGNC:72547
Mus musculus	FIS1	MGD	MGI:1913687
Others	FIS1	NCBI