2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Cytoskeleton
  3. Mitochondrial Metabolism Reactive Oxygen Species (ROS) Dynamin
  4. SP11

SP11 is a mitochondrial fission protein 1 (Fis1) inhibitor with an IC50 of 9.4 μM. SP11 binds only to activated Fis1 by engaging Cys41. SP11 preserves mitochondrial integrity and function during oxidative stress, inhibits hydrogen peroxide-induced mitochondrial ROS production, mitochondrial fragmentation, and Drp1 mitochondrial translocation. SP11 can be used for the research of parkinson’s disease.

For research use only. We do not sell to patients.

SP11

SP11 Chemical Structure

CAS No. : 2629218-24-0

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

SP11 Related Antibodies

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Description

SP11 is a mitochondrial fission protein 1 (Fis1) inhibitor with an IC50 of 9.4 μM. SP11 binds only to activated Fis1 by engaging Cys41. SP11 preserves mitochondrial integrity and function during oxidative stress, inhibits hydrogen peroxide-induced mitochondrial ROS production, mitochondrial fragmentation, and Drp1 mitochondrial translocation. SP11 can be used for the research of parkinson’s disease[1].

In Vitro

SP11 potently and specifically inhibits to the Cys41 residue of activated Fis1Thr34Asp, with an IC50 of 9.4 μM[1].
SP11 (250 nM; 24 h) prevents hydrogen peroxide-induced mitochondrial ROS production, fragmentation and increased Drp1 translocation to the mitochondria in HK-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SP11 Related Antibodies

Western Blot Analysis[1]

Cell Line: HK-2 human renal proximal tubule epithelial cells
Concentration: 250 nM (pre-incubation, then co-treated with 100 μM hydrogen peroxide)
Incubation Time: 30 min (pre-incubation); 24 h (co-treatment)
Result: Significantly reduced hydrogen peroxide-induced Drp1 recruitment to mitochondria.
Lowered Drp1/VDAC levels to near vehicle control levels.
Molecular Weight

346.87

Formula

C18H19ClN2OS
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

CN(C(CCl)=O)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (72.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8829 mL 14.4146 mL 28.8292 mL
5 mM 0.5766 mL 2.8829 mL 5.7658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8829 mL 14.4146 mL 28.8292 mL 72.0731 mL
5 mM 0.5766 mL 2.8829 mL 5.7658 mL 14.4146 mL
10 mM 0.2883 mL 1.4415 mL 2.8829 mL 7.2073 mL
15 mM 0.1922 mL 0.9610 mL 1.9219 mL 4.8049 mL
20 mM 0.1441 mL 0.7207 mL 1.4415 mL 3.6037 mL
25 mM 0.1153 mL 0.5766 mL 1.1532 mL 2.8829 mL
30 mM 0.0961 mL 0.4805 mL 0.9610 mL 2.4024 mL
40 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8018 mL
50 mM 0.0577 mL 0.2883 mL 0.5766 mL 1.4415 mL
60 mM 0.0480 mL 0.2402 mL 0.4805 mL 1.2012 mL
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SP11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP112629218-24-0SP 11SP-11Mitochondrial MetabolismReactive Oxygen Species (ROS)DynaminDrp1reactive oxygen speciesHK-2 cellsFis1parkinson’s diseaseInhibitorinhibitorinhibit

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