Nqo2 - N-ribosyldihydronicotinamide:quinone reductase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 291084

Summary

Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside Quinone Reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nqo2 Products (1)

mRNA Protein Name
NM_001004214.1 NP_001004214.1 ribosyldihydronicotinamide dehydrogenase [quinone]

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in memory IEP
IEP: Inferred from expression pattern
17512093 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23554738 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20861374 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
23554738 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
22508052 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribosyldihydronicotinamide dehydrogenase [quinone]

  • NAD(P)H dehydrogenase, quinone 2

  • NAD(P)H quinone dehydrogenase 2

  • NRH dehydrogenase [quinone] 2

  • NRH:quinone oxidoreductase 2

  • QR2

  • quinone reductase 2

  • ribosyldihydronicotinamide dehydrogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117393 Bisindolylmaleimide III Inhibitor 98.95% Unkown
HY-180168 NQO2 activator-1 Activator / Unkown
HY-W843391 Caricotamide Activator / Unkown
HY-112454 Bisindolylmaleimide III hydrochloride Inhibitor / Unkown
HY-N9765 threo-Guaiacylglycerol β-coniferyl ether Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nqo2 NCBI NCBI:4835