Oprk1 - opioid receptor, kappa 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29335

Summary

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Oprk1 Products (2)

mRNA Protein Name
NM_001318742.1 NP_001305671.1 kappa-type opioid receptor isoform 1x
NM_017167.3 NP_058863.1 kappa-type opioid receptor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21041644 RGD
enables receptor serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
27865836 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
24919534 RGD
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
27865836 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9645969 RGD
involved in conditioned place preference IMP
IMP: Inferred from mutant phenotype
21549821 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
11961051 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
21041644 RGD
involved in maternal behavior IDA
IDA: Inferred from direct assay
22641418 RGD
involved in negative regulation of luteinizing hormone secretion IMP
IMP: Inferred from mutant phenotype
23391862 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9572309 RGD
involved in positive regulation of dopamine secretion IDA
IDA: Inferred from direct assay
17568430 RGD
involved in positive regulation of eating behavior IMP
IMP: Inferred from mutant phenotype
17456590 RGD
involved in positive regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
16648139 RGD
involved in positive regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
12815037 RGD
involved in response to acrylamide IEP
IEP: Inferred from expression pattern
22197712 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
9645969 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
8904783 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
9645969 RGD
involved in response to insulin IDA
IDA: Inferred from direct assay
10995763 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
9645969 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
28509375 RGD
involved in sensory perception of temperature stimulus IMP
IMP: Inferred from mutant phenotype
21041644 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
26365878 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
17120286 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17120286 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
26365878 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17120286 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17120286 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
11746715 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
11746715 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
26365878 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
26365878 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
11746715 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kappa-type opioid receptor

  • K-OR-1

  • KOR-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116163 ML350 / Unkown
HY-121800 ML138 / Unkown
HY-RS09802 OPRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21006 Oprk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27523 Oprk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oprk1 NCBI NCBI:4986