OPRK1 - opioid receptor kappa 1 Gene

Also Known as KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4986

About OPRK1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,225,724-53,251,637 (from NCBI)

This gene has 5 transcripts (splice variants), 264 orthologues and 17 paralogues. Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues.

Summary

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

OPRK1 Products (3)

mRNA Protein Name
NM_000912.5 NP_000903.2 kappa-type opioid receptor isoform 1
NM_001282904.2 NP_001269833.1 kappa-type opioid receptor isoform 2
NM_001318497.2 NP_001305426.1 kappa-type opioid receptor isoform 1x

OPRK1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (76 - 330)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

kappa-type opioid receptor

  • Opiate receptor, kappa-1

OPRK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OPRK1 P41145 APLNR Homo sapiens P35414
BRET
31668922
Intra
OPRK1 P41145 APLNR Homo sapiens P35414
BRET
22200678
Intra
OPRK1 P41145 NKG7 Homo sapiens Q16617
Validated Y2H
32296183
Intra
OPRK1 P41145 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
16431922
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Morphine Dependence
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Cocaine Dependence
Opiate Dependence

  • Opioid Dependence

  • Opioid Addiction

  • Opiate Addiction

  • Opioid Type Dependence

  • Opioid-Related Disorders

  • Opium Dependence

  • Narcotic Dependence

  • Intravenous Narcotism

  • Narcotism Nos

  • Oral Narcotism Nos
Drug Dependence
Neonatal Abstinence Syndrome

  • Drug Withdrawal Syndrome In Newborn
Opioid Abuse

  • Opioid-Related Disorders
Cocaine Abuse

  • Cocaine-Related Disorders
Pain Agnosia

  • Analgesia
Agnosia

  • Dyspraxia

  • Primary Visual Agnosia

  • Dyspraxia Syndrome

  • Monomodal Visual Amnesia

  • Visual Amnesia

  • Agnosia, Primary Visual

  • Apraxias

  • Alexia
Withdrawal Disorder

  • Withdrawal Syndrome

  • Substance Withdrawal Syndrome
Retinitis Pigmentosa 44

  • RP44

  • Retinitis Pigmentosa, Type 44
Spinocerebellar Ataxia 23

  • Spinocerebellar Ataxia Type 23

  • SCA23

  • Ataxia, Spinocerebellar, Type 23
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Substance Dependence
Rett Syndrome

  • Atypical Rett Syndrome

  • RTT

  • Rett Disorder

  • Rts

  • Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

  • Rett Syndrome, Preserved Speech Variant

  • Rett Syndrome, Atypical

  • Rett'S Disorder

  • Rett Syndrome Variant

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

  • Cerebroatrophic Hyperammonemia

  • Rett Like Syndrome

  • Rett'S Syndrome

  • Atypical Rtt

  • Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

  • Rett Syndrome Preserved Speech Variant

  • Rett Syndrome Zappella Variant

  • Rett Syndrome, Zappella Variant
Substance Abuse

  • Substance-Related Disorders

  • Substance Abuse Problem
Specific Developmental Disorder
Constipation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116163 ML350 / Unkown
HY-121800 ML138 / Unkown
HY-RS09802 OPRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21006 Oprk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27523 Oprk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus OPRK1 VGNC VGNC:68633
Bos taurus OPRK1 VGNC VGNC:32439
Canis familiaris OPRK1 VGNC VGNC:44133
Macaca mulatta OPRK1 VGNC VGNC:104467
Rattus norvegicus OPRK1 RGD RGD:69426
Mus musculus OPRK1 MGD MGI:97439
Others OPRK1 NCBI