Acvr1b - activin A receptor type 1B Gene

Also Known as Skr2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29381

About Acvr1b

Primary_assembly 7: 132,286,275-132,329,673 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 271 orthologues, 11 paralogues and is associated with 10 phenotypes. Biased expression in Kidney (RPKM 81.1), Brain (RPKM 55.3) and 9 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; activin binding activity; and activin receptor activity, type I. Predicted to contribute to activin-activated receptor activity and growth factor binding activity. Involved in central nervous system development; development of primary female sexual characteristics; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cell surface and cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ACVR1B (Activin A receptor type 1B). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1b Products (1)

mRNA Protein Name
NM_199230.2 NP_954700.1 activin receptor type-1B precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in activin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17040568 RGD
involved in cardiac fibroblast cell development IMP
IMP: Inferred from mutant phenotype
27477354 RGD
involved in development of primary female sexual characteristics IEP
IEP: Inferred from expression pattern
11897700 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
27477354 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17040568 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22332899 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr1b Protein Structure

Activin_recp

Activin_recp: pfam01064 (31 - 103)

GS

GS: smart00467 (176 - 206)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (210 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

activin receptor type-1B

  • ACTR-IB

  • ALK-4

  • Serine/threonine-protein kinase receptor R2

  • activin A receptor, type IB

  • activin receptor type IB

  • activin receptor-like kinase 4

Recombinant Acvr1b Proteins

Cat. No. Product Name Accession Purity
HY-P76718 Activin RIB/ALK-4 Protein, Rat (HEK293, Fc) P80202 (S24-E126) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174785 Human ACVR1B mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr1b NCBI NCBI:91