2. Gene
  3. ACVR1B - activin A receptor type 1B Gene

ACVR1B - activin A receptor type 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ALK4; SKR2; ACTRIB; ACVRLK4

Gene ID: 91 | Gene type: protein coding

About ACVR1B

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,951,699-51,997,078 (from NCBI)

This gene has 7 transcripts (splice variants), 271 orthologues and 11 paralogues. Ubiquitous expression in kidney (RPKM 15.7), colon (RPKM 11.9) and 25 other tissues.

Summary

This gene encodes an Activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

ACVR1B Products(9)

mRNA Protein Name
NM_004302.5 NP_004293.1 activin receptor type-1B isoform a precursor
NM_020328.4 NP_064733.3 activin receptor type-1B isoform c precursor
XM_047429857.1 XP_047285813.1 activin receptor type-1B isoform X1
XM_011538966.4 XP_011537268.1 activin receptor type-1B isoform X2
XM_047429858.1 XP_047285814.1 activin receptor type-1B isoform X1
XM_011538967.4 XP_011537269.1 activin receptor type-1B isoform X4
NM_020327.4 NP_064732.3 activin receptor type-1B isoform b
XM_017020201.3 XP_016875690.1 activin receptor type-1B isoform X3
XM_047429856.1 XP_047285812.1 activin receptor type-1B isoform X1

ACVR1B Protein Structure

Activin_recp

Activin_recp: Activin types I and II receptor domain (33 - 104)

TGF_beta_GS

TGF_beta_GS: Transforming growth factor beta type I GS-motif (177 - 205)

Pkinase

Pkinase: Protein kinase domain (209 - 492)

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  • 505 a.a.
Protein Preferred Names Protein Names

activin receptor type-1B

activin A receptor, type IB

activin A receptor, type II-like kinase 4

activin receptor-like kinase 4

serine/threonine-protein kinase receptor R2

Recombinant ACVR1B Proteins

Cat. No. Product Name Accession Purity
HY-P7485 Activin RIB/ALK-4 Protein, Human (HEK293, His) P36896 (S24-E126) ≥95%
HY-P75571 Activin RIB/ALK-4 Protein, Human (HEK293, Fc) P36896 (S24-E126) ≥95%
HY-P75572 Activin RIB/ALK-4 Protein, Human (HEK293, His-Fc) P36896 (S24-E126) ≥95%

Related Diseases

Diseases Alias
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3

ARCI3

Lamellar Ichthyosis 5

Collodion Baby, Self-Healing

Ichthyosis, Lamellar, 5, Formerly

Li5, Formerly

Li5

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 3
Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries

DTGA1

Dextro-Looped Transposition Of The Great Arteries

DTGA

Congenitally Uncorrected Transposition Of The Great Arteries

Congenitally Uncorrected Transposition Of The Great Vessels

D-Tga

Isolated Ventriculoarterial Discordance

Ventriculoarterial Discordance With Atrioventricular Concordance

Great Vessels Transposition

Dextro-Looped Transposition Of The Great Arteries 1

Transposition Of The Great Arteries, Dextro-Looped 1

Arteries, Great, Transposition, Dextro-Looped

Ventriculoarterial Discordance, Isolated

D-Transposition Of The Great Arteries

Dextro-Transposition Of The Great Arteries

Complete Transposition

Tga

Tgv

Transposition Of The Great Vessels

Transposition Of Great Vessels

Transposition Of The Great Arteries Dextro-Looped 1

Discordant Ventriculoarterial Connection

Complete Transposition Of Great Vessels

Great Vessels Complete Transposition

Total Great Vessel Transposition

Transposition Of Great Arteries

Complete Tga - [Transposition Of The Great Arteries]

Tga - [Transposition Of Great Arteries]

Tgv - [Transposition Of Great Vessels]

Transposition Of Great Vessels Nos

Transposed Vessels Nos
Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease

Hht

Osler-Weber-Rendu Disease

Telangiectasia, Hereditary Hemorrhagic

Osler Hemorrhagic Telangiectasia Syndrome

Orw Disease

Osler Weber Rendu Syndrome

Osler-Rendu-Weber Disease

Osler-Weber-Rendu Syndrome

Rendu-Osler Disease

Telangiectasia Hereditary Hemorrhagic

Telangiectasia Hemorrhagic, Hereditary

Hht - [Hereditary Haemorrhagic Telangiectasia]

Osler Haemorrhagic Telangiectasia Syndrome
Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva

Progressive Myositis Ossificans

FOP

Progressive Ossifying Myositis

Myositis Ossificans

Stone Man Syndrome

Man Of Stone

Myositis Ossificans Progressive

Diffuse Progressive Ossifying Polymyositis

Fibrodysplasia Ossificans Congenita

Myositis Ossificans Progressiva, Site Unspecified

Münchmeyer Disease

Fop - [Fibrodysplasia Ossificans Progressiva]

Progressive Myositis Ossificans Calcification
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A / Unkown
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ACVR1B RGD RGD:735207
Felis catus ACVR1B VGNC VGNC:59563
Macaca mulatta ACVR1B VGNC VGNC:69446
Mus musculus ACVR1B MGD MGI:1338944
Canis familiaris ACVR1B VGNC VGNC:37562
Bos taurus ACVR1B VGNC VGNC:25593
Others ACVR1B NCBI