Numb - NUMB, endocytic adaptor protein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29419

Summary

Predicted to enable alpha-catenin binding activity; beta-catenin binding activity; and Cadherin binding activity. Involved in positive regulation of dendrite morphogenesis; regulation of neuron differentiation; and regulation of postsynaptic specialization assembly. Located in apical part of cell and dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human NUMB (NUMB endocytic adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Numb Products (5)

mRNA Protein Name
NM_001411953.1 NP_001398882.1 protein numb homolog isoform 2
NM_001411954.1 NP_001398883.1 protein numb homolog isoform 1
NM_001411955.1 NP_001398884.1 protein numb homolog isoform 3
NM_001411956.1 NP_001398885.1 protein numb homolog isoform 4
NM_133287.2 NP_579821.2 protein numb homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16394100 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
16394100 RGD
involved in regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
8805372 RGD
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
16394100 RGD
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
16394100 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12702648 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
16394100 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16394100 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16394100 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
16394100 RGD
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
16394100 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein numb homolog

  • numb gene homolog

  • numb homolog

Numb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Numb Q3MUI1 Ap2a2 Rattus norvegicus Q66HM2
Pull Down
17022975
Intra
Numb Q3MUI1 Ywhah Rattus norvegicus P68511
Pull Down
17022975
Intra
Numb Q3MUI1 Ap2b1 Rattus norvegicus P62944-2
Pull Down
17022975
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119734 Gossypolone 96.28% Unkown
HY-N7013 Hydroxy-Epsilon-Sanshool / Unkown
HY-N7014 Hydroxyl-​γ-​isosanshool / Unkown
HY-RS09681 NUMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12639 β-Sanshool Activator / Unkown
HY-N12768 Rhodojaponin VI Inhibitor / Unkown
HY-RS19926 Numb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26428 Numb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Numb NCBI NCBI:8650