Epas1 - endothelial PAS domain protein 1 Gene

Also Known as HLF; Hif2a; HIF2 alpha; HIF-2 alpha

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29452

Summary

Enables DNA-binding transcription factor activity and cobalt ion binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including norepinephrine biosynthetic process; positive regulation of lung alveolus development; and regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Used to study acute kidney failure and intermittent claudication. Biomarker of artery disease (multiple); glucose metabolism disease (multiple); polycystic kidney disease; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Epas1 Products (1)

mRNA Protein Name
NM_023090.2 NP_075578.2 endothelial PAS domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11237857 RGD
enables cobalt ion binding IDA
IDA: Inferred from direct assay
11688986 RGD
contributes to sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12675925 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
12099714 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
12099714 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12099714 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20496369 RGD
involved in norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19457096 RGD
involved in positive regulation of dopamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19457096 RGD
involved in positive regulation of lung alveolus development IEP
IEP: Inferred from expression pattern
23962064 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11237857 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
12675925 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelial PAS domain-containing protein 1

  • EPAS-1

  • HIF-2-alpha

  • HIF2-alpha

  • hypoxia inducible factor 2, alpha subunit

  • hypoxia inducible factor 2a

  • hypoxia-inducible factor 2-alpha

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-147426 Zifcasiran Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04409 EPAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147426A Zifcasiran sodium Inhibitor / Unkown
HY-B0660S1 Eicosapentaenoic acid 1,2,3,4,5-13C5 Activator / Unkown
HY-RS18998 Epas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25487 Epas1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epas1 NCBI NCBI:2034