GSTT2 - glutathione S-transferase theta 2 (gene/pseudogene) Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2953

About GSTT2

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,980,134-23,983,915 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 515 orthologues and 14 paralogues. Broad expression in adrenal (RPKM 18.4), skin (RPKM 14.6) and 20 other tissues.

Summary

The protein encoded by this gene, Glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each Other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

GSTT2 Products (2)

mRNA Protein Name
NM_000854.4 NP_000845.2 glutathione S-transferase theta-2 isoform a
NM_001302670.1 NP_001289599.1 glutathione S-transferase theta-2 isoform b

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
1417752 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
1417752 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTT2 Protein Structure

GST_N

GST_N: Glutathione S-transferase, N-terminal domain (19 - 74)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (128 - 199)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

glutathione S-transferase theta-2

  • GST class-theta-2

Recombinant GSTT2 Proteins

Cat. No. Product Name Accession Purity
HY-P75802 GSTT2B Protein, Human (HEK293, His) P0CG29 (M1-P244) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05888 GSTT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19439 Gstt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25931 Gstt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GSTT2 MGD MGI:106188
Rattus norvegicus GSTT2 RGD RGD:69362