GSTT2 - glutathione S-transferase theta 2 (gene/pseudogene) Gene

Homo sapiens

Gene ID: 2953 | Gene type: protein coding

About GSTT2

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,980,134-23,983,915 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 515 orthologues and 14 paralogues. Broad expression in adrenal (RPKM 18.4), skin (RPKM 14.6) and 20 other tissues.

Summary

The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

GSTT2 Products(2)

mRNA	Protein	Name
NM_000854.4	NP_000845.2	glutathione S-transferase theta-2 isoform a
NM_001302670.1	NP_001289599.1	glutathione S-transferase theta-2 isoform b

GSTT2 Protein Structure

GST_N

GST_C

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

glutathione S-transferase theta-2

GST class-theta-2

Recombinant GSTT2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75802	GSTT2B Protein, Human (HEK293, His)	P0CG29 (M1-P244)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05888	GSTT2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GSTT2	MGD	MGI:106188
Rattus norvegicus	GSTT2	RGD	RGD:69362

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