Timp2 - TIMP metallopeptidase inhibitor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29543

Summary

Enables Integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including positive regulation of Adenylate Cyclase activity; positive regulation of neuron differentiation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]

Timp2 Products (1)

mRNA	Protein	Name
NM_021989.3	NP_068824.1	metalloproteinase inhibitor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	15901773	RGD
enables metalloendopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	15901773	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	15901773	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15901773	RGD
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	15901773	RGD
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	17532789	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15901773	RGD
involved in positive regulation of adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	15901773	RGD
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	15901773	RGD
involved in regulation of Rap protein signal transduction	IDA IDA: Inferred from direct assay	15901773	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	17822627	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17491697	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15901773	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	15901773	RGD
located in growth cone	IDA IDA: Inferred from direct assay	15901773	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15901773	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
metalloproteinase inhibitor 2	TIMP-2 tissue inhibitor of metalloproteinase 2 tissue inhibitor of metalloproteinases 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14539	TIMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W012856	3-Ethyltoluene		/	Unkown
HY-RS17383	Timp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23838	Timp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Timp2	NCBI	NCBI:7077