Gsn - gelsolin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 296654

Summary

Enables actin binding activity. Involved in several processes, including cellular response to cadmium ion; oligodendrocyte development; and phosphatidylinositol-mediated signaling. Located in several cellular components, including myelin sheath; perinuclear region of cytoplasm; and ruffle. Part of protein-containing complex. Biomarker of hypothyroidism and lung disease. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]

Gsn Products (1)

mRNA Protein Name
NM_001004080.1 NP_001004080.1 gelsolin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
16280379 RGD
Biological Process GO Annotation Evidence References Source
involved in actin filament depolymerization IMP
IMP: Inferred from mutant phenotype
11861757 RGD
involved in actin polymerization or depolymerization IDA
IDA: Inferred from direct assay
16280379 RGD
involved in cellular response to cadmium ion IDA
IDA: Inferred from direct assay
16280379 RGD
involved in oligodendrocyte development IEP
IEP: Inferred from expression pattern
7817780 RGD
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
24505034 RGD
involved in positive regulation of p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
24505034 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
12899944 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
12899944 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
14574581 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
16280379 RGD
located in apical ectoplasmic specialization IDA
IDA: Inferred from direct assay
11861757 RGD
located in basal ectoplasmic specialization IDA
IDA: Inferred from direct assay
11861757 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
2829631 RGD
located in glial filament IDA
IDA: Inferred from direct assay
25744577 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17960831 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16280379 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15823548 RGD
located in ruffle IDA
IDA: Inferred from direct assay
16280379 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gelsolin

  • ADF

  • actin-depolymerizing factor

  • brevin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133870 Itaconate-alkyne 98.01% Unkown
HY-RS18449 Gsn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05867 GSN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24931 Gsn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsn NCBI NCBI:2934