Cacna1d - calcium voltage-gated channel subunit alpha1 D Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29716

Summary

Enables PDZ domain binding activity; ankyrin binding activity; and high voltage-gated Calcium Channel activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of CREB transcription factor activity; and positive regulation of transport. Located in several cellular components, including apical plasma membrane; dendrite membrane; and sarcolemma. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1d Products (1)

mRNA Protein Name
NM_001389225.2 NP_001376154.1 voltage-dependent L-type calcium channel subunit alpha-1D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
17287512 RGD
enables ankyrin binding IPI
IPI: Inferred from physical interaction
21859974 RGD
enables high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
18322004 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20627102 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
11487617 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
17050707 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion import IMP
IMP: Inferred from mutant phenotype
16706838 RGD
involved in calcium ion transport IDA
IDA: Inferred from direct assay
21859974 RGD
involved in calcium-mediated signaling IDA
IDA: Inferred from direct assay
7479909 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
21822937 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
21378599 RGD
involved in memory IEP
IEP: Inferred from expression pattern
12591156 RGD
involved in metal ion transport IMP
IMP: Inferred from mutant phenotype
17287512 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of CREB transcription factor activity IMP
IMP: Inferred from mutant phenotype
16706838 RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: Inferred from mutant phenotype
25675390 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
23229155 RGD
involved in positive regulation of membrane depolarization IDA
IDA: Inferred from direct assay
7760845 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
21859974 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19593990 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14637163 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21822937 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
16706838 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
19136044 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
19665524 RGD
located in primary dendrite IDA
IDA: Inferred from direct assay
19136044 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
21378599 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit alpha-1D

  • CaV1.3alpha1

  • RBD

  • brain class D

  • calcium channel alpha-1 subunit

  • calcium channel, L type, alpha-1 polypeptide

  • calcium channel, voltage-dependent, L type, alpha 1D subunit

  • voltage-dependent calcium channel subunit alpha1D

  • voltage-gated calcium channel

Cacna1d Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cacna1d P27732 Gabbr2 Rattus norvegicus O88871
Pull Down
20627102
Intra
Cacna1d P27732 Gabbr2 Rattus norvegicus O88871
IF
20627102
Intra
Cacna1d P27732 Gabbr2 Rattus norvegicus O88871
Anti Bait CoIP
20627102
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01794 CACNA1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20625 Cacna1d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27134 Cacna1d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1d NCBI NCBI:776