Gabbr2 - gamma-aminobutyric acid type B receptor subunit 2 Gene

Also Known as Gpr51

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83633

Summary

Enables G protein-coupled GABA Receptor activity. Involved in gamma-aminobutyric acid signaling pathway and neuron-glial cell signaling. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 59 and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Gabbr2 Products (1)

mRNA Protein Name
NM_031802.2 NP_113990.2 gamma-aminobutyric acid type B receptor subunit 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled GABA receptor activity IDA
IDA: Inferred from direct assay
11389174 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19590495 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15147298 RGD
involved in gamma-aminobutyric acid signaling pathway IDA
IDA: Inferred from direct assay
11389174 RGD
involved in neuron-glial cell signaling IGI
IGI: Inferred from genetic interaction
10196584 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
14657159 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
14657159 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14657159 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
14657159 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid type B receptor subunit 2

  • G-protein coupled receptor 51

  • GABA-B R2 receptor

  • GABA-B receptor 2

  • GABA-B-R2

  • GABA-BR2

  • GABABR2

  • gamma-aminobutyric acid (GABA) B receptor 2

  • gb2

Gabbr2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gabbr2 O88871 Gabbr1 Rattus norvegicus Q9Z0U4
Anti Tag CoIP
19590495
Intra
Gabbr2 O88871 Gabbr1 Rattus norvegicus Q9Z0U4
FRET
19590495
Intra
Gabbr2 O88871 Gabbr1 Rattus norvegicus Q9Z0U4
BRET
19590495
Intra
Gabbr2 O88871 Gabbr1 Rattus norvegicus Q9Z0U4
Anti Tag CoIP
21552208
Intra
Gabbr2 O88871 Cacna1d Rattus norvegicus P27732
Anti Bait CoIP
20627102
Intra
Gabbr2 O88871 Cacna1d Rattus norvegicus P27732
Y2H
20627102
Intra
Gabbr2 O88871 Cacna1d Rattus norvegicus P27732
Pull Down
20627102
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05205 GABBR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabbr2 NCBI NCBI:9568