Gabbr1 - gamma-aminobutyric acid type B receptor subunit 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81657

Summary

Enables G protein-coupled GABA Receptor activity; extracellular matrix protein binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of Adenylate Cyclase activity; neuron-glial cell signaling; and regulation of secretion. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in several cellular components, including axolemma; dendrite; and synaptic vesicle. Is integral component of plasma membrane. Part of GABA Receptor complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study visual epilepsy. Biomarker of hypertension and visual epilepsy. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Gabbr1 Products (1)

mRNA Protein Name
NM_031028.3 NP_112290.2 gamma-aminobutyric acid type B receptor subunit 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled GABA receptor activity IDA
IDA: Inferred from direct assay
10457184 RGD
enables G protein-coupled GABA receptor activity IMP
IMP: Inferred from mutant phenotype
12054677 RGD
enables extracellular matrix protein binding IMP
IMP: Inferred from mutant phenotype
15304491 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15304491 RGD
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
15304491 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9069281 RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15147298 RGD
involved in gamma-aminobutyric acid signaling pathway IDA
IDA: Inferred from direct assay
15147298 RGD
involved in negative regulation of adenylate cyclase activity IMP
IMP: Inferred from mutant phenotype
15147298 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15147298 RGD
involved in negative regulation of dopamine secretion IDA
IDA: Inferred from direct assay
12872287 RGD
involved in negative regulation of epinephrine secretion IMP
IMP: Inferred from mutant phenotype
14568556 RGD
involved in negative regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
14654095 RGD
involved in negative regulation of synaptic transmission IDA
IDA: Inferred from direct assay
12604336 RGD
involved in neuron-glial cell signaling IGI
IGI: Inferred from genetic interaction
10196584 RGD
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
12054677 RGD
involved in positive regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
18765663 RGD
involved in positive regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
12218349 RGD
involved in regulation of glutamate secretion IDA
IDA: Inferred from direct assay
15561437 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16246313 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
12435490 RGD
Cellular Component GO Annotation Evidence References Source
part of GABA receptor complex IDA
IDA: Inferred from direct assay
15304491 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
14657159 RGD
located in axolemma IDA
IDA: Inferred from direct assay
17924569 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
17241134 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
16983643 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
17924569 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
18765663 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
14657159 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
17924569 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17241134 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15304491 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14657159 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
14657159 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
15304491 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
17924569 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid type B receptor subunit 1

  • GABA-B receptor 1

  • GABA-B-R1

  • GABA-BR1

  • GABABR1

  • gamma-aminobutyric acid (GABA) B receptor 1

  • gb1

Gabbr1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gabbr1 Q9Z0U4 Gabbr2 Rattus norvegicus O88871
FRET
21552208
Intra
Gabbr1 Q9Z0U4 Gabbr2 Rattus norvegicus O88871
Anti Tag CoIP
19590495
Intra
Gabbr1 Q9Z0U4 Gabbr2 Rattus norvegicus O88871
FRET
21063387
Intra
Gabbr1 Q9Z0U4 Gabbr2 Rattus norvegicus O88871
FRET
19590495
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05204 GABBR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabbr1 NCBI NCBI:2550