TMOD3 - tropomodulin 3 Gene

Also Known as UTMOD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29766

About TMOD3

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:51,829,653-51,915,725 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 45.0), lung (RPKM 23.8) and 24 other tissues.

Summary

Enables Cadherin binding activity involved in cell-cell adhesion. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within actin Cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]

TMOD3 Products (1)

mRNA Protein Name
NM_014547.5 NP_055362.1 tropomodulin-3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
37126682 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMOD3 Protein Structure

Tropomodulin

Tropomodulin: Tropomodulin (1 - 146)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

tropomodulin-3

  • tropomodulin 3 (ubiquitous)

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis Type 5

  • Amyotrophic Lateral Sclerosis 5

  • Als5
Aromatase Excess Syndrome

  • AEXS

  • Increased Aromatase Activity

  • Familial Hyperestrogenism

  • Hereditary Prepubertal Gynecomastia

  • Aromatase Activity, Increased

  • Familial Gynecomastia Due To Increased Aromatase Activity

  • Hereditary Gynecomastia

  • Gynecomastia, Familial

  • Familial Gynecomastia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14761 TMOD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22865 Tmod3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29379 Tmod3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMOD3 VGNC VGNC:47625
Macaca mulatta TMOD3 VGNC VGNC:78572
Rattus norvegicus TMOD3 RGD RGD:1311030
Bos taurus TMOD3 VGNC VGNC:106986
Felis catus TMOD3 VGNC VGNC:66379
Mus musculus TMOD3 MGD MGI:1355315
Others TMOD3 NCBI