Ndrg2 - N-myc downstream regulated gene 2 Gene

Also Known as Ndr2; SYLD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 29811

Summary

Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and respiratory system. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Ndrg2 Products (14)

mRNA Protein Name
NM_001145959.1 NP_001139431.1 protein NDRG2 isoform 2
NM_001360264.1 NP_001347193.1 protein NDRG2 isoform 3
NM_001360265.1 NP_001347194.1 protein NDRG2 isoform 1
NM_001360266.1 NP_001347195.1 protein NDRG2 isoform 1
NM_001360267.1 NP_001347196.1 protein NDRG2 isoform 1
NM_001360268.1 NP_001347197.1 protein NDRG2 isoform 1
NM_001360269.1 NP_001347198.1 protein NDRG2 isoform 1
NM_001360270.1 NP_001347199.1 protein NDRG2 isoform 4
NM_001360271.1 NP_001347200.1 protein NDRG2 isoform 2
NM_001360272.1 NP_001347201.1 protein NDRG2 isoform 2
NM_001360273.1 NP_001347202.1 protein NDRG2 isoform 2
NM_001360274.1 NP_001347203.1 protein NDRG2 isoform 2
NM_001360276.1 NP_001347205.1 protein NDRG2 isoform 2
NM_013864.2 NP_038892.1 protein NDRG2 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19815093 MGI
acts upstream of or within negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
19815093 MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
16520977 MGI
acts upstream of or within regulation of platelet-derived growth factor production IMP
IMP: Inferred from mutant phenotype
19815093 MGI
acts upstream of or within regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
19815093 MGI
acts upstream of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
16520977 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16520977 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16520977 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein NDRG2

  • N-myc downstream regulated 2

  • N-myc downstream-regulated gene 2 protein

  • protein Ndr2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-100443 PX20606 Agonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P10359A TAT-QFNP12 acetate Inhibitor 95.90% Unkown
HY-139418 PX20350 Agonist / Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-RS09115 NDRG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20061 Ndrg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26565 Ndrg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndrg2 NCBI NCBI:57447