Shmt2 - serine hydroxymethyltransferase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 299857

Summary

Enables several functions, including L-allo-threonine aldolase activity; glycine hydroxymethyltransferase activity; and pyridoxal phosphate binding activity. Involved in L-serine biosynthetic process; glycine biosynthetic process from serine; and positive regulation of cell population proliferation. Located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial matrix. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Shmt2 Products (3)

mRNA Protein Name
NM_001008322.2 NP_001008323.1 serine hydroxymethyltransferase, mitochondrial isoform 1
NM_001393833.1 NP_001380762.1 serine hydroxymethyltransferase, mitochondrial isoform 2
NM_001393834.1 NP_001380763.1 serine hydroxymethyltransferase, mitochondrial isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-allo-threonine aldolase activity IDA
IDA: Inferred from direct assay
3110140 RGD
enables amino acid binding IPI
IPI: Inferred from physical interaction
3110140 RGD
enables glycine hydroxymethyltransferase activity IDA
IDA: Inferred from direct assay
3110140 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
3110140 RGD
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
3110140 RGD
Biological Process GO Annotation Evidence References Source
involved in L-serine biosynthetic process IDA
IDA: Inferred from direct assay
10457370 RGD
involved in glycine biosynthetic process IDA
IDA: Inferred from direct assay
3110140 RGD
involved in glycine biosynthetic process from serine IDA
IDA: Inferred from direct assay
3110140 RGD
involved in glycine metabolic process IDA
IDA: Inferred from direct assay
10457370 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12138190 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
4107181 RGD
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
4107181 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine hydroxymethyltransferase, mitochondrial

  • serine hydroxymethyltransferase 2 (mitochondrial)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182019 HDAC11-IN-5 Activator / Unkown
HY-177092 AGF347 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shmt2 NCBI NCBI:6472