Lrp1 - LDL receptor related protein 1 Gene

Also Known as LRP-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 299858

Summary

Enables coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of transport; regulation of cytosolic calcium ion concentration; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrp1 Products (1)

mRNA Protein Name
NM_001130490.1 NP_001123962.1 prolow-density lipoprotein receptor-related protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
18321860 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
10514495 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12153398 RGD
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
15272003 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular lipid catabolic process IMP
IMP: Inferred from mutant phenotype
26506094 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
8930375 RGD
involved in chemoattraction of axon IMP
IMP: Inferred from mutant phenotype
26598525 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17065459 RGD
involved in negative regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
20197276 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
22674573 RGD
involved in negative regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
20197276 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
24086544 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17314289 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
23132925 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
24865476 RGD
involved in positive regulation of Schwann cell migration IMP
IMP: Inferred from mutant phenotype
20197276 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
21040802 RGD
involved in positive regulation of axon extension involved in regeneration IDA
IDA: Inferred from direct assay
23867460 RGD
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: Inferred from mutant phenotype
21290408 RGD
involved in positive regulation of cholesterol import IMP
IMP: Inferred from mutant phenotype
22454363 RGD
involved in positive regulation of collateral sprouting of injured axon IDA
IDA: Inferred from direct assay
23867460 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
18321860 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
24865476 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
24086544 RGD
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
19299462 RGD
involved in positive regulation of protein transport IMP
IMP: Inferred from mutant phenotype
11100124 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
20940000 RGD
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
8626514 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in apical part of cell IDA
IDA: Inferred from direct assay
20488202 RGD
located in axonal growth cone IDA
IDA: Inferred from direct assay
26598525 RGD
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
16190982 RGD
located in dendrite IDA
IDA: Inferred from direct assay
9046007 RGD
located in endosome IDA
IDA: Inferred from direct assay
14701798 RGD
located in insulin-responsive compartment IDA
IDA: Inferred from direct assay
19864425 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9046007 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolow-density lipoprotein receptor-related protein 1

  • low density lipoprotein receptor-related protein 1

  • low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P4073 ANG1005 98.83% Phase 3

Pre-clinical Phase

Bioactive Molecules (22)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-100447 TM5275 sodium Inhibitor 98.97% Unkown
HY-P10502A L57 acetate 99.01% Unkown
HY-P10502 L57 99.44% Unkown
HY-172699A DSPE-PEG3400-ANG 95.0% Unkown
HY-165426 HB-230 91.2% Unkown
HY-N9454 Garcinoic acid / Unkown
HY-RS23105 Lrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183626 PAI-1-IN-1 99.45% Unkown
HY-172698 DSPE-PEG1000-ANG / Unkown
HY-172699 DSPE-PEG2000-ANG / Unkown
HY-172700 DSPE-PEG5000-ANG / Unkown
HY-179459 SJ-300 Inhibitor / Unkown
HY-187487A DOPE-PEG2000-ANG / Unkown
HY-P10911 IETP2 Ligand / Unkown
HY-P11413 PAI-1 / Unkown
HY-RS01706 C1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07792 LRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07796 LRP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183877 YO-2 / Unkown
HY-RS16670 Lrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22618 Lrp1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS29133 Lrp1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990202 Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) Inhibitor 98.10% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp1 NCBI NCBI:4035