Pias1 - protein inhibitor of activated STAT, 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300772

Summary

Enables SUMO transferase activity; protein C-terminus binding activity; and protein domain specific binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of nitrogen compound metabolic process; and visual learning. Located in nucleus. Biomarker of focal segmental glomerulosclerosis. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Apr 2022]

Pias1 Products (1)

mRNA Protein Name
NM_001106829.3 NP_001100299.3 E3 SUMO-protein ligase PIAS1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
23118920 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14500712 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
22406621 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19198660 RGD
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20818504 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20818504 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16135793 RGD
involved in positive regulation of protein sumoylation IMP
IMP: Inferred from mutant phenotype
25031400 RGD
involved in positive regulation of smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
16135793 RGD
involved in protein-DNA complex assembly IMP
IMP: Inferred from mutant phenotype
16135793 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
12799075 RGD
involved in visual learning IMP
IMP: Inferred from mutant phenotype
25031400 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W062696 BC-1382 Inhibitor 99.36% Unkown
HY-RS10473 PIAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20081 Pias1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26584 Pias1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pias1 NCBI NCBI:8554