RORA - RAR-related orphan receptor A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300807

About RORA

Primary_assembly 8: 69,301,733-70,025,931 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 395 orthologues, 19 paralogues and is associated with 8 phenotypes. Biased expression in Adrenal (RPKM 181.6), Muscle (RPKM 18.7) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

RORA Products (3)

mRNA Protein Name
XM_008766410.3 XP_008764632.1 nuclear receptor ROR-alpha isoform X3
XM_039082823.1 XP_038938751.1 nuclear receptor ROR-alpha isoform X1
XM_039082824.1 XP_038938752.1 nuclear receptor ROR-alpha isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24615205 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
15781226 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RORA Protein Structure

NR_DBD_ROR

NR_DBD_ROR: cd06968 (65 - 159)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (271 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 523 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-alpha

  • RAR-related orphan receptor alpha

  • nuclear receptor ROR-alpha-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-402601 Desethyl-SID 7969543 Control 98.83% Unkown
HY-RS12126 RORA Human Pre-designed siRNA Set A / Unkown
HY-RS12127 Rora Mouse Pre-designed siRNA Set A / Unkown
HY-RS12128 RORA Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens RORA NCBI NCBI:6095