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Pdcd1 - programmed cell death 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 301626

About Pdcd1

Primary_assembly 9: 94,418,791-94,431,937 reverse strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 106 orthologues and is associated with 59 phenotypes. Biased expression in Thymus (RPKM 22.3), Spleen (RPKM 5.7) and 3 other tissues.

Summary

Predicted to be involved in negative regulation of immune response and positive regulation of T cell apoptotic process. Predicted to act upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in plasma membrane. Biomarker of anti-basement membrane glomerulonephritis; periodontitis; and pre-eclampsia. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdcd1 Products (2)

mRNA	Protein	Name
NM_001106927.1	NP_001100397.1	programmed cell death protein 1 precursor
NM_001106927.1	NP_001100397.1	programmed cell death protein 1 precursor

Pdcd1 Protein Structure

IgV_PD1

0
100
200
287 a.a.

Protein Preferred Names	Protein Names
programmed cell death protein 1	programmed cell death protein 1-like

Recombinant Pdcd1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73347	PD-1 Protein, Rat (HEK293, His)	D3ZIN8/NP_001100397.1 (L25-Q167)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73348	PD-1 Protein, Rat (HEK293, Fc)	D3ZIN8/NP_001100397.1 (L25-Q167)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99668	Iparomlimab	Inhibitor	96.64%	Phase 4
HY-P990074	Enlonstobart	Inhibitor	99.27%	Phase 3
HY-P990700	Tobemstomig		97.06%	Phase 2
HY-P990701	Lomvastomig		99.9%	Phase 2
HY-P991698	Liscastobart	Inhibitor	98.73%	Phase 2
HY-P99698	Lesabelimab	Inhibitor	97.34%	Phase 2
HY-P991345	MEDI-0680	Inhibitor	/	Phase 2
HY-P991348	BAT-1306	Inhibitor	/	Phase 2
HY-P990702	Pradusinstobart		97.767%	Phase 1
HY-P991346	CC-90006	Inhibitor	/	Phase 1
HY-P991349	GNR-051	Inhibitor	/	Phase 1
HY-P991353	Sym-021	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147273	Fulimetibant	Antagonist	99.60%	Unkown
HY-RS10185	PDCD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10186	Pdcd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10187	Pdcd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10190	PDCD1LG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18210	Pdcd1lg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24687	Pdcd1lg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990072	Lipustobart	Inhibitor	99.9%	Unkown
HY-P990722	Danvilostomig		98.38%	Unkown
HY-P991113	Abazistobart	Inhibitor	96.045%	Unkown
HY-P990912	Cugrastomig		98.46%	Unkown
HY-P990486	Anti-PDCD1/PD-1/CD279 Antibody	Inhibitor	/	Unkown
HY-P991347	AM0001	Inhibitor	/	Unkown
HY-P991351	RTX-002	Agonist	/	Unkown
HY-P992478	TY101	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdcd1	NCBI	NCBI:5133