2. Gene
  3. Mink1 - misshapen-like kinase 1 Gene

Mink1 - misshapen-like kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as MEKKK 6

Gene ID: 303259 | Gene type: protein coding

About Mink1

Primary_assembly 10: 55,278,391-55,330,782 forward strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 204 orthologues, 36 paralogues and is associated with 2 phenotypes. Biased expression in Brain (RPKM 281.3), Kidney (RPKM 229.4) and 9 other tissues.

Summary

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including dendrite morphogenesis; neuron cellular homeostasis; and regulation of AMPA receptor activity. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mink1 Products(3)

mRNA Protein Name
NM_001414353.1 NP_001401282.1 misshapen-like kinase 1 isoform 3
NM_001271136.2 NP_001258065.1 misshapen-like kinase 1 isoform 2
NM_001414352.1 NP_001401281.1 misshapen-like kinase 1 isoform 1

Mink1 Protein Structure

STKc_MAP4K4_6_N

STKc_MAP4K4_6_N: cd06636 (7 - 288)

PHA03307

PHA03307: cl33723 (548 - 844)

CNH

CNH: smart00036 (1065 - 1363)

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  • 1384 a.a.
Protein Preferred Names Protein Names

misshapen-like kinase 1

GCK family kinase MiNK

MAPK/ERK kinase kinase kinase 6

MEK kinase kinase 6

misshapen/NIK-related kinase

mitogen-activated protein kinase kinase kinase kinase 6

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17437A Mefloquine hydrochloride 99.99% Yes
HY-17437 Mefloquine / Unkown
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111754 DMX-5804 Inhibitor 99.83% Unkown
HY-108591 L-364,373 Activator 99.67% Unkown
HY-RS08454 MINK1 Human Pre-designed siRNA Set A / Unkown
HY-RS08455 Mink1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08456 Mink1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mink1 NCBI NCBI:50488