Mink1 - misshapen-like kinase 1 Gene

Also Known as MEKKK 6

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 303259

About Mink1

Primary_assembly 10: 55,278,391-55,330,782 forward strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 204 orthologues, 36 paralogues and is associated with 2 phenotypes. Biased expression in Brain (RPKM 281.3), Kidney (RPKM 229.4) and 9 other tissues.

Summary

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including dendrite morphogenesis; neuron cellular homeostasis; and regulation of AMPA Receptor activity. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mink1 Products (3)

mRNA	Protein	Name
NM_001414353.1	NP_001401282.1	misshapen-like kinase 1 isoform 3
NM_001271136.2	NP_001258065.1	misshapen-like kinase 1 isoform 2
NM_001414352.1	NP_001401281.1	misshapen-like kinase 1 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21048137	RGD
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	21048137	RGD
involved in neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	21048137	RGD
involved in regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	21048137	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	21048137	RGD
involved in regulation of postsynapse organization	IEP IEP: Inferred from expression pattern	21048137	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	21048137	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21048137	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21048137	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	21048137	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	21048137	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mink1 Protein Structure

STKc_MAP4K4_6_N

PHA03307

CNH

0
300
600
900
1200
1384 a.a.

Protein Preferred Names	Protein Names
misshapen-like kinase 1	GCK family kinase MiNK MAPK/ERK kinase kinase kinase 6 MEK kinase kinase 6 misshapen/NIK-related kinase mitogen-activated protein kinase kinase kinase kinase 6

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17437A	Mefloquine hydrochloride		99.98%	Yes
HY-17437	Mefloquine		99.79%	Yes

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111754	DMX-5804	Inhibitor	99.83%	Unkown
HY-108591	L-364,373	Activator	99.65%	Unkown
HY-RS08454	MINK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08455	Mink1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08456	Mink1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W402208	MAP4K4-IN-7	Inhibitor	/	Unkown
HY-178775	PI4K-IN-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mink1	NCBI	NCBI:50488