Ercc6 - ERCC excision repair 6, chromatin remodeling factor Gene

Predicted to enable several functions, including ATP binding activity; protein C-terminus binding activity; and protein tyrosine kinase activator activity. Involved in DNA protection; regulation of transcription elongation from RNA polymerase II promoter; and transcription-coupled nucleotide-excision repair. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Used to study Cockayne syndrome B. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; age related macular degeneration 5; and primary ovarian insufficiency 11. Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]