EHD2 - EH domain containing 2 Gene

Homo sapiens

Also known as PAST2

Gene ID: 30846 | Gene type: protein coding

About EHD2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:47,713,422-47,743,134 (from NCBI)

This gene has 5 transcripts (splice variants), 259 orthologues and 10 paralogues. Broad expression in fat (RPKM 140.8), lung (RPKM 41.0) and 18 other tissues.

Summary

This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin Cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]

EHD2 Products(1)

mRNA	Protein	Name
NM_014601.4	NP_055416.2	EH domain-containing protein 2

EHD2 Protein Structure

Dynamin_N

EF-hand_4

0
100
200
300
400
500
543 a.a.

Protein Preferred Names

Protein Names

EH domain-containing protein 2

PAST homolog 2

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04222	EHD2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EHD2	VGNC	VGNC:28372
Mus musculus	EHD2	MGD	MGI:2154274
Felis catus	EHD2	VGNC	VGNC:61764
Canis familiaris	EHD2	VGNC	VGNC:40246
Macaca mulatta	EHD2	VGNC	VGNC:109621
Rattus norvegicus	EHD2	RGD	RGD:1560856