Itgb2 - integrin subunit beta 2 Gene

Also Known as Cd18

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309684

Summary

Contributes to cell adhesion molecule binding activity. Involved in several processes, including leukocyte migration; positive regulation of angiogenesis; and regulation of cellular biosynthetic process. Located in cell surface and plasma membrane. Used to study nephritis and pneumonia. Biomarker of allergic rhinitis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (Integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Itgb2 Products (1)

mRNA Protein Name
NM_001037780.2 NP_001032869.2 integrin beta-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to cell adhesion molecule binding IMP
IMP: Inferred from mutant phenotype
16825578 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
1672643 RGD
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8938183 RGD
involved in cellular extravasation IMP
IMP: Inferred from mutant phenotype
10363598 RGD
involved in endothelial cell migration IMP
IMP: Inferred from mutant phenotype
16825578 RGD
involved in leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
11804664 RGD
involved in leukocyte migration involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
10363598 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
9062344 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
16825578 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
9062344 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8938183 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-2

  • CD18 leukocyte adhesion molecule

  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1

  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1

  • macrophage antigen 1 (mac-1) beta subunit)

  • macrophage antige

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99946 Erlizumab Inhibitor 98.49% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06965 ITGB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16847 Itgb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23288 Itgb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb2 NCBI NCBI:3689