Zeb2 - zinc finger E-box binding homeobox 2 Gene

Also Known as Zfhx1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311071

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; R-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including nervous system development; neural crest cell migration; and positive regulation of signal transduction. Predicted to be located in chromatin; cytosol; and nuclear lumen. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Zeb2 Products (1)

mRNA Protein Name
NM_001033701.2 NP_001028873.2 zinc finger E-box-binding homeobox 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in astrocyte activation IDA
IDA: Inferred from direct assay
34852714 RGD
involved in endothelial cell migration IMP
IMP: Inferred from mutant phenotype
31881206 RGD
involved in endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
31881206 RGD
involved in fibroblast activation IDA
IDA: Inferred from direct assay
30336567 RGD
involved in myofibroblast differentiation IEP
IEP: Inferred from expression pattern
24155330 RGD
involved in negative regulation of fibroblast migration IDA
IDA: Inferred from direct assay
30336567 RGD
involved in positive regulation of myofibroblast contraction IDA
IDA: Inferred from direct assay
30336567 RGD
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
34852714 RGD
involved in regulation of blood-brain barrier permeability IMP
IMP: Inferred from mutant phenotype
34334113 RGD
involved in regulation of myofibroblast cell apoptotic process IMP
IMP: Inferred from mutant phenotype
34321385 RGD
involved in response to oxygen-glucose deprivation IMP
IMP: Inferred from mutant phenotype
34321385 RGD
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
31784544 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger E-box-binding homeobox 2

  • zinc finger homeobox 1b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131445 RJW100 Activator 99.93% Unkown
HY-173557 PRMT7-IN-2 98.26% Unkown
HY-RS17821 Zeb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16026 ZEB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24289 Zeb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zeb2 NCBI NCBI:9839