Tmprss6 - transmembrane serine protease 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315388

Summary

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in cellular iron ion homeostasis; proteolysis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular space. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human TMPRSS6 (transmembrane serine protease 6). [provided by Alliance of Genome Resources, Apr 2022]

Tmprss6 Products (2)

mRNA Protein Name
NM_001130556.1 NP_001124028.1 transmembrane protease serine 6
NM_001130556.1 NP_001124028.1 transmembrane protease serine 6
Protein Preferred Names Protein Names

transmembrane protease serine 6

  • transmembrane protease, serine 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-177662A Sapablursen sodium Inhibitor / Phase 3
HY-177662 Sapablursen Inhibitor 96.05% Phase 2
HY-147278A Manusiran sodium Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991637 Exerenibart Inhibitor 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130136A TMPRSS6-IN-1 TFA Inhibitor / Unkown
HY-130136 TMPRSS6-IN-1 Inhibitor / Unkown
HY-147278 Manusiran Inhibitor / Unkown
HY-P11260 MD5 Inhibitor / Unkown
HY-RS14773 TMPRSS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180217 WGU55 Inhibitor / Unkown
HY-RS19286 Tmprss6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25776 Tmprss6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992451 RLYB331 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmprss6 NCBI NCBI:164656