Tmprss6 - transmembrane serine protease 6 Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in cellular iron ion homeostasis; proteolysis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular space. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human TMPRSS6 (transmembrane serine Protease 6). [provided by Alliance of Genome Resources, Apr 2022]