Cd2ap - CD2-associated protein Gene

Also Known as CMS

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 316258

Summary

Enables several functions, including beta-catenin binding activity; Cadherin binding activity; and protein C-terminus binding activity. Involved in several processes, including cell-cell adhesion; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of receptor-mediated endocytosis. Located in cell leading edge; endocytic vesicle; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 3. Orthologous to human CD2AP (CD2 associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Cd2ap Products (1)

mRNA Protein Name
NM_181475.3 NP_852140.2 CD2-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
16617054 RGD
enables cadherin binding IPI
IPI: Inferred from physical interaction
15910750 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15001553 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16617054 RGD
enables vascular endothelial growth factor receptor binding IDA
IDA: Inferred from direct assay
15001553 RGD
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
15910750 RGD
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
16617054 RGD
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15001553 RGD
involved in regulation of receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
15001553 RGD
involved in vesicle organization IDA
IDA: Inferred from direct assay
15001553 RGD
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
15910750 RGD
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15001553 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15910750 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16617054 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD2-associated protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02224 CD2AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21509 Cd2ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28027 Cd2ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd2ap NCBI NCBI:23607