FOXA3 - forkhead box A3 Gene

Also Known as FKHH3; HNF3G; TCF3G

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3171

About FOXA3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,864,326-45,873,797 (from NCBI)

This gene has 2 transcripts (splice variants), 89 orthologues and 42 paralogues. Biased expression in liver (RPKM 21.0), stomach (RPKM 17.8) and 6 other tissues.

Summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

FOXA3 Products (1)

mRNA Protein Name
NM_004497.3 NP_004488.2 hepatocyte nuclear factor 3-gamma

FOXA3 Protein Structure

Forkhead_N

Forkhead_N: Forkhead N-terminal region (16 - 116)

Forkhead

Forkhead: Forkhead domain (117 - 212)

HNF_C

HNF_C: HNF3 C-terminal domain (301 - 322)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

hepatocyte nuclear factor 3-gamma

  • HNF-3-gamma

FOXA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FOXA3 P55318 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra
FOXA3 P55318 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra
FOXA3 P55318 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra
FOXA3 P55318 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
FOXA3 P55318 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
FOXA3 P55318 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adult Acute Monocytic Leukemia

  • Adult Acute Monoblastic And Acute Monocytic Leukemia
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168534 WX-02-23 99.88% Unkown
HY-RS05038 FOXA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174678 Human FOXA3 mRNA / Unkown
HY-RS20927 Foxa3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27444 Foxa3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FOXA3 VGNC VGNC:29079
Felis catus FOXA3 VGNC VGNC:67602
Macaca mulatta FOXA3 VGNC VGNC:72709
Canis familiaris FOXA3 VGNC VGNC:40945
Mus musculus FOXA3 MGD MGI:1347477
Rattus norvegicus FOXA3 RGD RGD:2809
Others FOXA3 NCBI