Gpr4 - G protein-coupled receptor 4 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319197

About Gpr4

Chromosome 7: 18,946,463-18,958,099 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 141 orthologues, 16 paralogues and is associated with 30 phenotypes. Ubiquitous expression in lung adult (RPKM 11.4), subcutaneous fat pad adult (RPKM 11.1) and 25 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in positive regulation of inflammatory response and regulation of vascular permeability. Acts upstream of or within several processes, including blood vessel development; negative regulation of angiogenesis; and response to acidic pH. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Gpr4 Products (1)

mRNA Protein Name
NM_175668.4 NP_783599.1 G-protein coupled receptor 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
17145776 MGI
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
17145776 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
17145776 MGI
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17145776 MGI
acts upstream of or within angiogenesis involved in wound healing IDA
IDA: Inferred from direct assay
17145776 MGI
acts upstream of or within glomerular mesangial cell development IMP
IMP: Inferred from mutant phenotype
17145776 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17145776 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
32058960 MGI
involved in regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
32058960 MGI
acts upstream of or within response to acidic pH IDA
IDA: Inferred from direct assay
17145776 MGI
acts upstream of or within response to acidic pH IMP
IMP: Inferred from mutant phenotype
17145776 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr4 Protein Structure

7tmA_GPR4

7tmA_GPR4: cd15366 (19 - 46)

7tmA_GPR4

7tmA_GPR4: cd15366 (19 - 298)

7tmA_GPR4

7tmA_GPR4: cd15366 (53 - 78)

7tmA_GPR4

7tmA_GPR4: cd15366 (91 - 121)

7tmA_GPR4

7tmA_GPR4: cd15366 (133 - 155)

7tmA_GPR4

7tmA_GPR4: cd15366 (179 - 208)

7tmA_GPR4

7tmA_GPR4: cd15366 (218 - 248)

7tmA_GPR4

7tmA_GPR4: cd15366 (266 - 291)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101784 NE 52-QQ57 99.80% Unkown
HY-101536 GPR4 antagonist 1 Antagonist 98.92% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr4 NCBI NCBI:2828