IFNA4 - interferon alpha 4 Gene

Also Known as INFA4; IFN-alpha4a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3441

About IFNA4

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,186,618-21,187,587 (from NCBI)

This gene has 1 transcript (splice variant), 586 orthologues and 16 paralogues.

Summary

Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

IFNA4 Products (1)

mRNA Protein Name
NM_021068.4 NP_066546.1 interferon alpha-4 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNA4 Protein Structure

Interferon

Interferon: Interferon alpha/beta domain (26 - 187)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

interferon alpha-4

  • IFN-alpha-4

IFNA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFNA4 P05014 ALDOA Homo sapiens P04075-2
Y2H Array
25416956
Intra
IFNA4 P05014 ALDOA Homo sapiens P04075-2
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNA4 Proteins

Cat. No. Product Name Accession Purity
HY-P72615 IFN-alpha 4/IFNA4 Protein, Human (HEK293, His) P05014 (C24-D189) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75821 IFN-alpha 4/IFNA4 Protein, Human (HEK293, Fc) P05014 (C24-D189) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75822 IFN-alpha 4/IFNA4 Protein, Human (sf9, His) P05014 (C24-D189) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Multisystem Inflammatory Syndrome In Children

  • Mis-C

  • Multisystem Inflammatory Disorder In Children And Adolescents

  • Paediatric Inflammatory Multisystemic Syndrome

  • Mic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06575 IFNA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174667 Human IFNA4 mRNA / Unkown
HY-RS18285 Ifna4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24763 Ifna4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IFNA4 RGD RGD:1306334