Hcar2 - hydroxycarboxylic acid receptor 2 Gene

Also Known as Hm74; Hm74b; Pumag; Niacr1; rHM74b; Gpr109a; Gpr109b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 353250

About Hcar2

Primary_assembly 12: 32,726,184-32,728,504 forward strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 164 orthologues, 13 paralogues and is associated with 5 phenotypes.

Summary

Enables nicotinic acid receptor activity. Involved in negative regulation of lipid catabolic process and positive regulation of Adiponectin secretion. Predicted to be located in cell junction and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human HCAR2 (hydroxycarboxylic acid receptor 2) and HCAR3 (hydroxycarboxylic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Hcar2 Products (1)

mRNA Protein Name
NM_181476.2 NP_852141.1 hydroxycarboxylic acid receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables nicotinic acid receptor activity IDA
IDA: Inferred from direct assay
19141678 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of lipid catabolic process IDA
IDA: Inferred from direct assay
19141678 RGD
involved in positive regulation of adiponectin secretion IDA
IDA: Inferred from direct assay
19141678 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hcar2 Protein Structure

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (24 - 301)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (25 - 51)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (58 - 83)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (96 - 126)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (138 - 160)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (181 - 210)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (220 - 250)

7tmA_HCAR1-3

7tmA_HCAR1-3: cd15201 (269 - 294)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

hydroxycarboxylic acid receptor 2

  • G protein-coupled receptor 109B

  • G protein-coupled receptor Hm74b

  • G-protein coupled receptor 109

  • G-protein coupled receptor 109A

  • G-protein coupled receptor HM74

  • interferon-gamma inducible gene, Puma-g

  • niacin receptor 1

  • nicotinic acid receptor

  • protein PUMA-G

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-30216A Leucic acid 98.38% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcar2 NCBI NCBI:338442