Fech - ferrochelatase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361338

Summary

Enables ferrochelatase activity. Involved in several processes, including cellular response to dexamethasone stimulus; response to lead ion; and response to platinum ion. Located in mitochondrion. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2022]

Fech Products (1)

mRNA Protein Name
NM_001108434.1 NP_001101904.1 ferrochelatase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ferrochelatase activity IDA
IDA: Inferred from direct assay
1316128 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
7917467 RGD
involved in heme biosynthetic process IDA
IDA: Inferred from direct assay
3955059 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
908300 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
12426626 RGD
involved in response to insecticide IEP
IEP: Inferred from expression pattern
6626236 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
4065316 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
3629603 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
3327437 RGD
involved in response to platinum ion IEP
IEP: Inferred from expression pattern
4040350 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
6721832 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ferrochelatase, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114758 Pyridoxal isonicotinoyl hydrazone Inhibitor 99.96% Unkown
HY-RS04857 FECH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20276 Fech Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26784 Fech Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fech NCBI NCBI:2235