Tyrobp - transmembrane immune signaling adaptor Tyrobp Gene

Also Known as Karap

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361537

Summary

Predicted to enable protein homodimerization activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of cytokine production. Predicted to act upstream of or within osteoclast differentiation and regulation of osteoclast development. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be active in cell surface. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Apr 2022]

Tyrobp Products (1)

mRNA Protein Name
NM_212525.1 NP_997690.1 TYRO protein tyrosine kinase-binding protein precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12077224 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TYRO protein tyrosine kinase-binding protein

  • DAP12

  • DNAX-activation protein 12

  • Tyro protein tyrosine kinase binding protein

  • killer cell activating receptor-associated protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15309 TYROBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21215 Tyrobp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27731 Tyrobp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyrobp NCBI NCBI:7305