2. Gene
  3. Idh2 - isocitrate dehydrogenase (NADP(+)) 2 Gene

Idh2 - isocitrate dehydrogenase (NADP(+)) 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361596 | Gene type: protein coding

About Idh2

Primary_assembly 1: 134,029,772-134,058,025 reverse strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 261 orthologues, 1 paralogue and is associated with 51 phenotypes. Biased expression in Heart (RPKM 8594.), Muscle (RPKM 35.7) and 4 other tissues.

Summary

Enables isocitrate dehydrogenase (NADP+) activity. Involved in several processes, including NADP biosynthetic process; negative regulation of glial cell proliferation; and negative regulation of matrix metallopeptidase secretion. Predicted to be located in cytosol and peroxisome. Predicted to be active in mitochondrion. Used to study status epilepticus. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung Cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2022]

Idh2 Products(1)

mRNA Protein Name
NM_001014161.1 NP_001014183.1 isocitrate dehydrogenase [NADP], mitochondrial precursor

Idh2 Protein Structure

PTZ00435

PTZ00435: PTZ00435 (38 - 450)

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  • 452 a.a.
Protein Preferred Names Protein Names

isocitrate dehydrogenase [NADP], mitochondrial

ICD-M

IDH

IDP

NADP(+)-specific ICDH

isocitrate dehydrogenase (NADP(+)) 2, mitochondrial

isocitrate dehydrogenase 2 (NADP+), mitochondrial

oxalosuccinate decarboxylase

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18690 Enasidenib Inhibitor 99.97% Yes
HY-18690A Enasidenib mesylate Inhibitor 99.85% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-104042 Vorasidenib Inhibitor 99.87% Phase 3
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131312 LY3410738 Inhibitor / Unkown
HY-149359 IHMT-IDH1-053 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Idh2 NCBI NCBI:3418