Idh2 - isocitrate dehydrogenase (NADP(+)) 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361596

About Idh2

Primary_assembly 1: 134,029,772-134,058,025 reverse strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 261 orthologues, 1 paralogue and is associated with 51 phenotypes. Biased expression in Heart (RPKM 8594.), Muscle (RPKM 35.7) and 4 other tissues.

Summary

Enables isocitrate dehydrogenase (NADP+) activity. Involved in several processes, including NADP biosynthetic process; negative regulation of glial cell proliferation; and negative regulation of matrix metallopeptidase secretion. Predicted to be located in cytosol and peroxisome. Predicted to be active in mitochondrion. Used to study status epilepticus. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung Cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2022]

Idh2 Products (1)

mRNA Protein Name
NM_001014161.1 NP_001014183.1 isocitrate dehydrogenase [NADP], mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables isocitrate dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
9354646 RGD
Biological Process GO Annotation Evidence References Source
involved in NADP biosynthetic process IMP
IMP: Inferred from mutant phenotype
21641335 RGD
involved in negative regulation of glial cell migration IMP
IMP: Inferred from mutant phenotype
22105553 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
21641335 RGD
involved in negative regulation of matrix metallopeptidase secretion IMP
IMP: Inferred from mutant phenotype
22105553 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Idh2 Protein Structure

PTZ00435

PTZ00435: PTZ00435 (38 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
Protein Preferred Names Protein Names

isocitrate dehydrogenase [NADP], mitochondrial

  • ICD-M

  • IDH

  • IDP

  • NADP(+)-specific ICDH

  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial

  • isocitrate dehydrogenase 2 (NADP+), mitochondrial

  • oxalosuccinate decarboxylase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104042 Vorasidenib Inhibitor 99.76% Yes
HY-18690 Enasidenib Inhibitor 99.93% Yes
HY-18690A Enasidenib mesylate Inhibitor 99.68% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-131312 Crelosidenib Inhibitor / Phase 1
HY-131312A Crelosidenib gentisate Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15734 AGI-6780 Inhibitor 99.26% Unkown
HY-164542 TQ05310 Inhibitor / Unkown
HY-149359 IHMT-IDH1-053 Inhibitor / Unkown
HY-145743 CP-17 Inhibitor / Unkown
HY-120765 BRD2879 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Idh2 NCBI NCBI:3418