Yap1 - Yes1 associated transcriptional regulator Gene

Also Known as Yap; YAP65

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363014

About Yap1

Primary_assembly 8: 5,095,722-5,167,010 reverse strand.mRatBN7.2:CM026981.1

This gene has 5 transcripts (splice variants), 219 orthologues, 1 paralogue and is associated with 22 phenotypes. Biased expression in Heart (RPKM 265.7), Lung (RPKM 223.8) and 9 other tissues.

Summary

Predicted to enable several functions, including proline-rich region binding activity; protein C-terminus binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and response to steroid hormone. Predicted to act upstream of or within several processes, including animal organ development; regulation of epithelial cell differentiation; and regulation of signal transduction. Predicted to be located in cytosol; female germ cell nucleus; and membrane. Predicted to be part of TEAD-YAP complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]

Yap1 Products (2)

mRNA Protein Name
NM_001394329.1 NP_001381258.1 transcriptional coactivator YAP1 2
NM_001394328.1 NP_001381257.1 transcriptional coactivator YAP1 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
31298560 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Yap1 Protein Structure

WW

WW: cd00201 (155 - 184)

WW

WW: smart00456 (212 - 244)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

transcriptional coactivator YAP1

  • 65 kDa Yes-associated protein

  • protein yorkie homolog

  • yes-associated protein 1

  • yes-associated protein YAP65 homolog

  • yorkie homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176542 TD034 Inhibitor 99.77% Unkown
HY-175649 LATS1/2-IN-1 Inhibitor / Unkown
HY-E70293 N-Acetylgalactosaminyltransferase 12 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Yap1 NCBI NCBI:10413