Aph1a - aph-1 homolog A, gamma secretase subunit Gene

Also Known as RGD1311546

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 365872

Summary

Predicted to enable endopeptidase activator activity; enzyme binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including Notch receptor processing; amyloid-beta formation; and proteolysis. Predicted to act upstream of or within metanephros development. Located in cytoplasmic vesicle; mitochondrion; and synaptic membrane. Is integral component of presynaptic membrane. Orthologous to human APH1A (aph-1 homolog A, gamma-secretase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Aph1a Products (1)

mRNA Protein Name
NM_001014255.1 NP_001014277.1 gamma-secretase subunit APH-1A

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20145246 RGD
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
20126630 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20126630 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-secretase subunit APH-1A

  • APH1A gamma secretase subunit

  • anterior pharynx defective 1 homolog A

  • anterior pharynx defective 1a homolog

Aph1a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Aph1a Q5PQQ3 P97887-PRO_0000025600 Rattus norvegicus P97887-PRO_0000025600
Anti Bait CoIP
12297508
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156012 PSEN1-IN-2 Inhibitor / Unkown
HY-156011 PSEN1-IN-1 Inhibitor / Unkown
HY-RS00817 APH1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21481 Aph1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27999 Aph1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aph1a NCBI NCBI:51107