PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) is a PSEN1 inhibitor. PSEN1-IN-1 inhibits PSEN1-APH1A and PSEN1-APH1B complex with IC50s of 19 and 5.5 nM. PSEN1-IN-1 can be used for Alzheimer's disease research.
For research use only. We do not sell to patients.
- CAS No.: 3054220-62-8
- Formula: C20H19ClF3NO3S
- Molecular Weight:445.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
19 and 5.5 nM for PSEN1-APH1A and PSEN1-APH1B complex[1]
Chemical Information
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CAS No. 3054220-62-8
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Molecular Weight 445.88
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Formula C20H19ClF3NO3S
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SMILES
FC(F)(C1=CC=C([C@H]([C@@H]2CC3)N(S(C4=CC=C(Cl)C=C4)(=O)=O)[C@@H]3C[C@@H]2O)C=C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSEN1-IN-1 Related Classifications
HY-156011 Related Classifications
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