ARF3 - ADP ribosylation factor 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 377

About ARF3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,935,723-48,957,487 (from NCBI)

This gene has 10 transcripts (splice variants), 253 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 69.0), colon (RPKM 28.8) and 24 other tissues.

Summary

ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute one family of the Ras superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. [provided by RefSeq, Oct 2022]

ARF3 Products (11)

mRNA Protein Name
NM_001412914.1 NP_001399843.1 ADP-ribosylation factor 3 isoform a
NM_001412915.1 NP_001399844.1 ADP-ribosylation factor 3 isoform a
NM_001412916.1 NP_001399845.1 ADP-ribosylation factor 3 isoform a
NM_001412918.1 NP_001399847.1 ADP-ribosylation factor 3 isoform a
NM_001412920.1 NP_001399849.1 ADP-ribosylation factor 3 isoform a
NM_001412926.1 NP_001399855.1 ADP-ribosylation factor 3 isoform a
NM_001412928.1 NP_001399857.1 ADP-ribosylation factor 3 isoform a
NM_001412930.1 NP_001399859.1 ADP-ribosylation factor 3 isoform a
NM_001412931.1 NP_001399860.1 ADP-ribosylation factor 3 isoform a
NM_001412932.1 NP_001399861.1 ADP-ribosylation factor 3 isoform b
NM_001659.3 NP_001650.1 ADP-ribosylation factor 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
IGI: Inferred from genetic interaction
24768165 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF3 Protein Structure

Arf

Arf: ADP-ribosylation factor family (7 - 176)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor 3

  • small GTP binding protein

ARF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARF3 P61204 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
ARF3 P61204 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
ARF3 P61204 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARF3 Proteins

Cat. No. Product Name Accession Purity
HY-P75583 ARF3 Protein, Human (His) P61204 (M1-K181) ≥ 95%, as determined by reducing SDS-PAGE.

ARF3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85947 Actin_sarcomeric muscle Antibody (YA5639) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat, Bovin, Pig, Chick

Related Diseases

Diseases Alias
Pectus Excavatum

  • Funnel Chest

  • Congenital Pectus Excavatum
Scoliosis
Heart, Malformation Of
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Hypotonia
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Cholera

  • Vibrio Cholerae Infection

  • Cholera - Vibrio Cholerae

  • Cholera Due To Vibrio Cholerae

  • Vibrio Cholerae

  • Cholera Syndrome

  • Asiatic Cholera

  • Epidemic Cholera
Smith-Mccort Dysplasia 1

  • Smith-Mccort Dysplasia

  • SMC1

  • Smc

  • Smith Mccort Dysplasia

  • Smith-Mccort Dwarfism
Retinitis Pigmentosa 7

  • Leber Congenital Amaurosis 18

  • RP7

  • Retinitis Pigmentosa 7, Digenic Form

  • Retinitis Pigmentosa 7 And Digenic Form

  • Retinitis Pigmentosa 7, Digenic

  • LCA18

  • Retinitis Pigmentosa 7 Digenic
Dyggve-Melchior-Clausen Disease

  • Dyggve-Melchior-Clausen Syndrome

  • DMC

  • Dmc Disease

  • Pseudo-Morquio Disease Type I

  • Dmc Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00895 ARF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20251 Arf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26759 Arf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARF3 RGD RGD:621273
Felis catus ARF3 VGNC VGNC:83498
Mus musculus ARF3 MGD MGI:99432
Others ARF3 NCBI