Parl - presenilin associated, rhomboid-like Gene

Also Known as Psarl; PSARL1; PRO2207; PSENIP2; D16Ertd607e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381038

Summary

Enables endopeptidase activity. Involved in several processes, including mitochondrial fusion; negative regulation of apoptotic signaling pathway; and regulation of Autophagy of mitochondrion. Located in mitochondrial inner membrane. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Apr 2022]

Parl Products (2)

mRNA Protein Name
NM_001005767.4 NP_001005767.1 presenilins-associated rhomboid-like protein, mitochondrial precursor
NM_001005767.4 NP_001005767.1 presenilins-associated rhomboid-like protein, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21138942 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18288109 MGI
Biological Process GO Annotation Evidence References Source
involved in mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
16713954 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16839884 MGI
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
16839884 MGI
involved in proteolysis IGI
IGI: Inferred from genetic interaction
21426348 MGI
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
21138942 MGI
involved in regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
21355049 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IMP
IMP: Inferred from mutant phenotype
16839884 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

presenilins-associated rhomboid-like protein, mitochondrial

  • mitochondrial intramembrane-cleaving protease PARL

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-152265A PARL-IN-1 TFA Activator / Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169380 PARL-IN-2 99.80% Unkown
HY-152265 PARL-IN-1 Activator 96.57% Unkown
HY-RS10044 PARL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18365 Parl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24844 Parl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parl NCBI NCBI:55486