Kif14 - kinesin family member 14 Gene

Also Known as D1Ertd367e; E130203M01

Species: Mus musculus

Gene Type: protein coding

Gene ID: 381293

About Kif14

Chromosome 1: 136,394,081-136,459,249 forward strand.GRCm39:CM000994.3

This gene has 8 transcripts (splice variants), 199 orthologues, 43 paralogues and is associated with 32 phenotypes. Biased expression in liver E14 (RPKM 3.3), liver E14.5 (RPKM 2.8) and 14 other tissues.

Summary

Enables ATP binding activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including brain development; negative regulation of neuron apoptotic process; and regulation of myelination. Predicted to be located in Flemming body; cytosol; and spindle midzone. Predicted to be part of Kinesin complex. Predicted to be active in microtubule. Predicted to colocalize with plasma membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (Kinesin family member 14). [provided by Alliance of Genome Resources, Apr 2022]

Kif14 Products (1)

mRNA	Protein	Name
NM_001287179.2	NP_001274108.1	kinesin-like protein KIF14

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	24949858	MGI
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	24949858	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	24949858	MGI
enables plus-end-directed microtubule motor activity	IDA IDA: Inferred from direct assay	24949858	MGI
enables tubulin binding	IDA IDA: Inferred from direct assay	24949858	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cell division	IMP IMP: Inferred from mutant phenotype	24931760	MGI
involved in cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in cerebellar Purkinje cell layer structural organization	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in cerebellar cortex development	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in cerebellar granular layer structural organization	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	23308235	MGI
NOT involved in microtubule depolymerization	IDA IDA: Inferred from direct assay	24949858	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in olfactory bulb development	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in regulation of cell maturation	IMP IMP: Inferred from mutant phenotype	24931760	MGI
involved in regulation of myelination	IMP IMP: Inferred from mutant phenotype	23308235	MGI
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	24931760	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kif14 Protein Structure

KISc_KIF1A_KIF1B

Kinesin_assoc

FHA_KIF14

SMC_prok_B

0
300
600
900
1200
1500
1674 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF14	N-3 kinesin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS07261	KIF14 Human Pre-designed siRNA Set A	/	Unkown
HY-RS07262	Kif14 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS07263	Kif14 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kif14	NCBI	NCBI:9928