Hcrtr2 - hypocretin (orexin) receptor 2 Gene

Mus musculus

Also known as OX2R; OXR2; OX2aR; OX2bR; mOXR2; mOX2aR; mOX2bR

Gene ID: 387285 | Gene type: protein coding

About Hcrtr2

Chromosome 9: 76,133,162-76,231,138 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 199 orthologues, 16 paralogues and is associated with 8 phenotypes. Low expression observed in reference dataset.

Summary

Enables orexin receptor activity. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Hcrtr2 Products(2)

mRNA	Protein	Name
NM_198962.4	NP_945200.1	orexin receptor type 2 isoform 1
NM_001364551.1	NP_001351480.1	orexin receptor type 2 isoform 2

Hcrtr2 Protein Structure

7tmA_OXR

Orexin_rec2

0
100
200
300
400
460 a.a.

Protein Preferred Names

Protein Names

orexin receptor type 2

hypocretin receptor type 2

orexin receptor type-2a

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS06054	HCRTR2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS06055	Hcrtr2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS06056	Hcrtr2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hcrtr2	NCBI	NCBI:3062

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