Hcrtr2 - hypocretin (orexin) receptor 2 Gene

Also Known as OX2R; OXR2; OX2aR; OX2bR; mOXR2; mOX2aR; mOX2bR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 387285

About Hcrtr2

Chromosome 9: 76,133,162-76,231,138 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 199 orthologues, 16 paralogues and is associated with 8 phenotypes. Low expression observed in reference dataset.

Summary

Enables orexin receptor activity. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Hcrtr2 Products (2)

mRNA Protein Name
NM_198962.4 NP_945200.1 orexin receptor type 2 isoform 1
NM_001364551.1 NP_001351480.1 orexin receptor type 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables orexin receptor activity IDA
IDA: Inferred from direct assay
15256537 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22028875 MGI
Biological Process GO Annotation Evidence References Source
involved in locomotion IGI
IGI: Inferred from genetic interaction
27585848 MGI
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15256537 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hcrtr2 Protein Structure

7tmA_OXR

7tmA_OXR: cd15208 (54 - 374)

7tmA_OXR

7tmA_OXR: cd15208 (55 - 81)

7tmA_OXR

7tmA_OXR: cd15208 (88 - 114)

7tmA_OXR

7tmA_OXR: cd15208 (126 - 156)

7tmA_OXR

7tmA_OXR: cd15208 (167 - 188)

7tmA_OXR

7tmA_OXR: cd15208 (219 - 248)

7tmA_OXR

7tmA_OXR: cd15208 (296 - 326)

7tmA_OXR

7tmA_OXR: cd15208 (342 - 367)

Orexin_rec2

Orexin_rec2: pfam03827 (385 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 460 a.a.
Protein Preferred Names Protein Names

orexin receptor type 2

  • hypocretin receptor type 2

  • orexin receptor type-2a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06054 HCRTR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02206 CD200R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06055 Hcrtr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06056 Hcrtr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcrtr2 NCBI NCBI:3062