LALBA - lactalbumin alpha Gene

Homo sapiens

Also known as LYZG; HAMLET

Gene ID: 3906 | Gene type: protein coding

About LALBA

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:48,567,684-48,571,845 (from NCBI)

This gene has 2 transcripts (splice variants), 109 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces Apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]

LALBA Products(2)

mRNA	Protein	Name
NM_001384350.1	NP_001371279.1	alpha-lactalbumin precursor
NM_002289.3	NP_002280.1	alpha-lactalbumin precursor

LALBA Protein Structure

Lys

0
100
142 a.a.

Protein Preferred Names

Protein Names

alpha-lactalbumin

lactose synthase B protein

Recombinant LALBA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70229	LALBA Protein, Human (HEK293, His)	P00709 (K20-L142)	≥95%

Related Diseases

Diseases

Alias

Milk Allergy

Milk Allergic Reaction	Milk Hypersensitivity
Allergy Milk

Skin Papilloma

Cutaneous Papilloma	Papilloma Of Skin
Papilloma Skin

Cow Milk Allergy

Bos Taurus Milk Allergy

Cow'S Milk Protein Sensitivity

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Breast Cystic Hypersecretory Carcinoma

Cystic Hypersecretory Carcinoma Of The Breast

Cystic Hypersecretory Duct Carcinoma Of The Breast

Lipid-Rich Carcinoma

Glycogen-Rich Carcinoma

Doid:0081028

Egg Allergy

Allergy To Eggs	Allergies Egg
Egg Hypersensitivity

Pregnancy Adenoma

Lactating Adenoma

Epilepsy, Juvenile Absence 1

Epilepsy, Juvenile Absence, Susceptibility To, 1	EJA1
JAE1	Juvenile Absence Epilepsy 1
Susceptibility To Juvenile Absence Epilepsy 1	Epilepsy, Juvenile Absence, Susceptibility To, Type 1
Absence Epilepsy

Cystic Basal Cell Carcinoma

Skin Cystic Basal Cell Carcinoma

Adenoid Basal Cell Carcinoma

Skin Adenoid Basal Cell Carcinoma

Basal Cell Carcinoma - Adenoid

Lactose Intolerance

Lactose Malabsorption	Lm - Lactose Malabsorption
Alactasia	Dairy Product Intolerance
Hypolactasia	Milk Sugar Intolerance
Cow Milk Enteropathy	Intolerance Or Malabsorption Of Lactose
Lm - [Lactose Malabsorption]	Milk Intolerance

Fish Allergy

Allergy To Fish

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2	Hereditary Mixed Polyposis Syndrome 2
Polyposis Syndrome, Mixed Hereditary 2	Polyposis Syndrome, Hereditary Mixed, Type 2

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07496	LALBA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LALBA	VGNC	VGNC:74224
Rattus norvegicus	LALBA	RGD	RGD:2987
Canis familiaris	LALBA	VGNC	VGNC:42563
Felis catus	LALBA	VGNC	VGNC:68002
Bos taurus	LALBA	VGNC	VGNC:30768
Mus musculus	LALBA	MGD	MGI:96742
Others	LALBA	NCBI

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