CYP4F3 - cytochrome P450 family 4 subfamily F member 3 Gene

Also Known as CPF3; CYP4F; LTB4H; CYPIVF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4051

About CYP4F3

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,640,897-15,662,825 (from NCBI)

This gene has 9 transcripts (splice variants), 364 orthologues and 12 paralogues. Biased expression in liver (RPKM 51.6), bone marrow (RPKM 29.9) and 6 other tissues.

Summary

This gene, CYP4F3, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]

CYP4F3 Products (4)

mRNA	Protein	Name
NM_000896.3	NP_000887.2	cytochrome P450 4F3 isoform a
NM_001199208.2	NP_001186137.1	cytochrome P450 4F3 isoform b
NM_001199209.2	NP_001186138.1	cytochrome P450 4F3 isoform b
NM_001369696.1	NP_001356625.1	cytochrome P450 4F3 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 20-aldehyde-leukotriene B4 20-monooxygenase activity	IDA IDA: Inferred from direct assay	9675028	GOA
enables 20-hydroxy-leukotriene B4 omega oxidase activity	IDA IDA: Inferred from direct assay	9675028	GOA
enables leukotriene-B4 20-monooxygenase activity	IDA IDA: Inferred from direct assay	9675028	GOA
enables long-chain fatty acid omega-1 hydroxylase activity	IDA IDA: Inferred from direct assay	18577768	GOA
enables long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	11461919	GOA
enables very long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	18577768	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid omega-oxidation	IDA IDA: Inferred from direct assay	18577768	GOA
involved in leukotriene B4 catabolic process	IDA IDA: Inferred from direct assay	9675028	GOA
involved in lipoxin A4 metabolic process	IDA IDA: Inferred from direct assay	15364545	GOA
involved in lipoxin B4 metabolic process	IDA IDA: Inferred from direct assay	15364545	GOA
involved in omega-hydroxylase P450 pathway	IDA IDA: Inferred from direct assay	15364545	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4F3 Protein Structure

p450

0
100
200
300
400
520 a.a.

Protein Preferred Names	Protein Names
cytochrome P450 4F3	20-HETE synthase

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 6	IBD6
Trichuriasis	Whipworm Infection Whipworm Disease Trichocephaliasis Infection By Trichuris Trichura Trichuriasis Infection Trichuris Trichiura Infection Infection By Trichuris Trichiura Trichocephalosis Infection By Trichocephalus Trichiura Infection By Trichuris Infection By Trichuris Trichiuria Trichuriosis Whipworm Infection Due To Trichuris Trichiura Trichocephalus Infestation Trichuris Infestation Whipworm Infestation
Neuropathy, Hereditary Sensory And Autonomic, Type Ic	HSAN1C Hsan Ic Hsn1c Hsn Ic Hereditary Sensory And Autonomic Neuropathy Type 1c Neuropathy, Hereditary Sensory And Autonomic, Type 1c Neuropathy, Hereditary Sensory, Type Ic Hereditary Sensory And Autonomic Neuropathy Type Ic Neuropathy, Hereditary Sensory And Autonomic, 1c Hereditary Sensory Neuropathy Type Ic Neuropathy, Hereditary Sensory/Autonomic, Type Ic Neuropathy, Sensory And Autonomic, Hereditary, Type Ic
Bietti Crystalline Corneoretinal Dystrophy	BCD Bietti Crystalline Dystrophy Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy Bietti Crystalline Retinopathy Bietti'S Crystalline Dystrophy Crystalline Retinopathy Dystrophy, Corneoretinal, Crystalline, Bietti
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03482	CYP4F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113777	22-HDHA		/	Unkown
HY-121888	20-HEPE	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP4F3	RGD	RGD:1305261
Others	CYP4F3	NCBI