DEFB103A - defensin beta 103A Gene

Also Known as BD-3; HBD3; HBP3; DEFB3; HBP-3; DEFB-3; DEFB103

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 414325

About DEFB103A

This gene has 1 transcript (splice variant), 1 gene allele, 94 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an Antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]

DEFB103A Products (1)

mRNA Protein Name
NM_001081551.4 NP_001075020.1 beta-defensin 103 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
11085990 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
11085990 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
15625724 GOA
involved in defense response to Gram-positive bacterium IEP
IEP: Inferred from expression pattern
11085990 GOA
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
21115716 GOA
involved in killing by host of symbiont cells IDA
IDA: Inferred from direct assay
16436752 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
11085990 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
21115716 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEFB103A Protein Structure

Defensin_beta

Defensin_beta: Beta defensin (30 - 64)

  • 0
  • 67 a.a.
Protein Preferred Names Protein Names

beta-defensin 103

  • beta-defensin 3

DEFB103A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DEFB103A P81534 SPATA31A7 Homo sapiens Q8IWB4
Validated Y2H
32296183
Intra
DEFB103A P81534 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
DEFB103A P81534 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 ODF4 Homo sapiens Q2M2E3
Validated Y2H
32296183
Intra
DEFB103A P81534 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
DEFB103A P81534 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
DEFB103A P81534 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
DEFB103A P81534 B3GALT5 Homo sapiens Q9Y2C3
Validated Y2H
32296183
Intra
DEFB103A P81534 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
DEFB103A P81534 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
DEFB103A P81534 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
DEFB103A P81534 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
DEFB103A P81534 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
DEFB103A P81534 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
DEFB103A P81534 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
DEFB103A P81534 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
DEFB103A P81534 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
DEFB103A P81534 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DEFB103A Proteins

Cat. No. Product Name Accession Purity
HY-P7137 BD-3 Protein, Human P81534 (G23-K67) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ileitis

  • Crohn'S Ileitis
Cardiomyopathy, Familial Hypertrophic, 12

  • Hypertrophic Cardiomyopathy 12

  • CMH12

  • Cardiomyopathy, Hypertrophic, 12

  • Cardiomyopathy Familial Hypertrophic 12

  • Cardiomyopathy, Familial Hypertrophic 12

  • Cardiomyopathy, Hypertrophic, Familial, Type 12
Cardiomyopathy, Familial Hypertrophic, 6

  • Hypertrophic Cardiomyopathy 6

  • CMH6

  • Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome

  • Cardiomyopathy, Familial Hypertrophic 6

  • Cardiomyopathy, Hypertrophic 6

  • Cardiomyopathy, Hypertrophic, Familial, Type 6
Eczema Herpeticum

  • Herpes Simplex Dermatitis

  • Herpes Simplex Eyelid Dermatitis

  • Kaposi Varicelliform Eruption

  • Herpes Simplex Dermatitis Of Eyelid

  • Herpes Simplex Virus Dermatitis

  • Herpes Simplex Virus Eyelid Dermatitis
Denture Stomatitis

  • Stomatitis, Denture

  • Denture Sore Mouth
Crohn'S Colitis

  • Crohn Disease
Oral Candidiasis

  • Thrush

  • Candidiasis Of Mouth

  • Oral Moniliasis

  • Thrush, Oral

  • Candidiasis, Oral

  • Oral Thrush

  • Candidiasis

  • Equine Thrush
Vaginal Disease

  • Vaginal Diseases
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03679 DEFB103A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DEFB103A MGD MGI:2675345
Rattus norvegicus DEFB103A RGD RGD:1561378